4-Dialkylaminomethyl-4-(m-methoxyphenyl)cyclohexanol類の合成
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For the purpose of testing their biological activity, 4-dialkylaminomethyl-4-(m-methoxyphenyl)cyclohexanol derivatives (XII, XIII, XIV) were synthesized. 4-Dimethyl-aminomethyl-4-(m-methoxyphenyl)cyclohexanone (XII) was synthesized from 4-dimethyl-aminomethyl-4-(m-methoxyphenyl)cyclohexanone ethylene acetal (XVIII), which was obtained from 1-(m-methoxyphenyl)-4-oxocyclohexanecarboxylic acid ethylene acetal (XV). 4-Dimethylaminomethyl-4-(m-hydroxyphenyl) cyclohexanol (XIII) was prepared by demethylation of 4-dimethylaminomethyl-4-(m-methoxyphenyl) cyclohexanol (VIII) with boron tribromide in dry dichloromethane. 4-Diethylaminomethyl-4-(m-methoxy-phenyl) cyclohexanol (XIV) was synthesized by the reduction of N, N-diethyl-1-(m-methoxy-phenyl)-4-acetoxycyclohexanecarboxamide (XXII) in tetrahydrofuran with lithium aluminum hydride. These compounds, XII, XIII, and XIV, did not show any significant analgesic activity.
- 社団法人日本薬学会の論文
- 1976-04-25
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