Rapid Synthesis of Oligodeoxynucleotides by using N-Methylimidazole as a Condensation Catalyst. Syntheses of Dodecanucleotides corresponding to Complementary Deoxyribonucleic Acid of the Tetrapeptide Fragments of Cholecystokinin-Pancreozymin and Vasoactiv
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概要
- 論文の詳細を見る
It has been found that N-methylimidazole (MeIm) activates stable condensing reagents such as 2,4,6-triisopropylbenzenesulfonyl-4-nitroimidazolide (TPSNI) and mesitylenesulfonyl-4-nitroimidazolide (MSNI). Fully protected trinucleotides which could serve as key intermediates were synthesized by using MeIm and TPSNI or MSNI. These trinucleotides were utilized in the syntheses of the dodecamers, dCATCCACCCCAT and dAGCCATCTGCTT, which correspond to the specific tetrapeptides of cholecystokininpancreozymin and vasoactive intestinal peptide.
- 社団法人日本薬学会の論文
- 1982-11-25
著者
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若林 利明
Faculty of Pharmaceutical Sciences, Osaka University
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若林 利明
Faculty Of Pharmaceutical Sciences Osaka University
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橘 真郎
エーザイ
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橘 真郎
Research Laboratories Eisai Co. Ltd.
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橘 真郎
Tsukuba Research Laboratories, Eisai Co., Ltd.,
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若林 利明
Tsukuba Research Laboratories, Eisai Co., Ltd.
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橘 真郎
Tsukuba Research Laboratories Eisai Co. Ltd.
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- Rapid Synthesis of Oligodeoxynucleotides by using N-Methylimidazole as a Condensation Catalyst. Syntheses of Dodecanucleotides corresponding to Complementary Deoxyribonucleic Acid of the Tetrapeptide Fragments of Cholecystokinin-Pancreozymin and Vasoactiv
- Studies on Transfer Ribonucleic Acids and Related Compounds. XXXVIII. A Rapid Method for the Synthesis of Ribooligonucleotides by using 3', 5'-Unsubstituted Nucleosides. Synthesis of a Hexanucleotide containing Anticodon Triplet of E. coli tRNA^_f.