A Synthetic Method Suitable for the Rapid Preparation of ^<13>N-Labeled Dermorphin Analogue, H-Try-D-Met(O)-Phe-Gly-NH_2 (SD-62)

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概要

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• A synthetic method suitable for the preparation of ^<13>N-labeled dermorphin analogue, H-Tyr-D-Met(O)-Phe-Gly-NH_2 (SD-62), was established; i.e., SD-62 was synthesized by a 5 min treatment of the active ester precursor with ammonia. When the ^<13>N-labeled SD-62,prepared by this method with [^<13>]ammonia, was administered into mice, the time profile of the radioactivity accumulation in the brain paralleled well that of the analgesic activity.

• 社団法人日本薬学会の論文
• 1991-10-25

著者

• 佐治 英郎

  京都大学 薬 放射性薬品化

• 横山 陽

  京都大学薬学部

• 横山 陽

  Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University

• 横山 陽

  京都大学

• 木曽 良明

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 木曽 良明

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

• 木曽 良明

  京都薬大

• 佐治 英郎

  Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University

• 赤路 健一

  京都薬科大学

• 飯沼 智

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 三本 勤

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 赤路 健一

  Department of Medicinal Chemistry, Kyoto Pharmaceutical University

• 三本 勤

  (株)ジャパンエナジー医薬・バイオ研究所

• 飯沼 智

  Department Of Medicinal Chemistry Kyoto Pharmaceutical University

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