Stable and Lipophilic Technetium-99m Dithiosemicarbazone Complexes with 5-6-5 Membered Chelate Ring Structure
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概要
- 論文の詳細を見る
Modification of the chelate ring structure of technetium-99m(^<99m>Tc) dithiosemicarbazone (DTS) chelate was carried out in pursuit of a more stable and lipophilic compound. A new DTS chelating molecule, pentane-2,4-dione bis(N-methylthiosemicarbazone) (PETS), with a 5-6-5 membered chelate ring stracture, was synthesized and labeled with ^<99m>Tc. PETS generated two ^<99m>Tc compounds as major products. Both had much higher stability and lipophilicity than a 5-5-5 membered ^<99m>Tc DTS compound, as well as great stability in plasma. Both ^<99m>Tc-PETS compounds were rapidly extracted by the brain and heart when injected into mice. Thus, the modified chelate ring structure afforded a preferable characteristics to DTS chelate as for the chelating site for technetium radiopharmaceuticals.
- 公益社団法人日本薬学会の論文
- 1990-11-25
著者
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横山 陽
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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荒野 泰
千葉大 大学院薬学研究院
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荒野 泰
千葉大学薬学部
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荒野 泰
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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矢吹 昌司
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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八幡 次成
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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堀内 和子
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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矢吹 昌司
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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堀内 和子
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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八幡 次成
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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