Mitochondria-Selective Reduction of ^<62>Cu-Pyruvaldehyde Bis(N^4-methylthiosemicarbazone) (^<62>Cu-PTSM) in the Murine Brain; a Novel Radiopharmaceutical for Brain Positron Emission Tomography (PET) Imaging
スポンサーリンク
概要
- 論文の詳細を見る
The retention mechanism of ^<62>Cu-pyruvaldehyde bis(N^4-methylthiosemicarbazone) (^<62>Cu-PTSM) in the murine brain was evaluated. For this purpose, stable Cu-PTSM was subjected to electron spin resonance spectrometry (ESR) and high performance liquid chromatography (HPLC) analysis to determine the valence state, coordination structure and tissue metabolism. In murine brain homogenate, ESR and HPLC analysis indicated the reduction and cleavage of Cu(II)-PTSM to Cu(I). This virtually irreversible reduction was specifically initiated by the mitochondrial enzymatic system in the murine brain.
- 社団法人日本薬学会の論文
- 1993-02-15
著者
-
藤林 靖久
福井大学高工ネルギー医学研究センター
-
横山 陽
京都大学薬学部
-
横山 陽
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
-
米倉 義晴
Department of Brain Pathophysiology, School of Medicine, Kyoto University
-
小西 淳二
Department of Nuclear Medicine, School of Medicine, Kyoto University
-
和田 耕一
Faculty of Pharmaceutical Sciences, Kyoto University
-
藤林 靖久
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
-
和田 耕一
Faculty Of Pharmaceutical Sciences Kyoto University
-
和田 耕一
Department of Radiopharmaceutical Chemistry Faculty of Pharmaceutical Sciences, Kyoto University
-
谷内 秀之
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences Kyoto University
-
横山 陽
京大
-
小西 淳二
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
-
谷内 秀之
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
関連論文
- ^F-FDGを用いた脳PET検査の健常者データベースにおける Transmission 撮像および減弱補正法の影響
- Studies on the Sulfur-containing Chelating Agents. XLVI. Hydrolysis of Thio-β-diketones and Related Amides in Acetonitrile-Water Mixture
- TcO4-イオンとヒト血清アルブミンの結合--アニオンとの拮抗〔英文〕
- Studies on the Sulfur-containing Chelating Agents. XLV. Kinetics of Ligand Exchange Reaction of Mercury-Monothiodibenzoylmethane Complex with Some Thiol Compounds by Stripping Solvent Extraction
- Studies on the Sulfur-containing Chelating Agents. XLIV. Kinetic Study of Ligand Exchange Reaction of Mercury-Aminopolycarboxylate with Monothiodibenzoylmethane by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents. XLIII. The Reaction of Thio-β-diketones and the Related Compounds with Iron (II) in the Presence of Pyridine
- Studies on the Sulfur-containing Chelating Agents. XLII. Solvent Extraction of Nickel (II) and Zinc (II) with N-(p-Substituted phenyl)-β-mercaptocinnamamides
- Studies on the Sulfur-containing Chelating Agents. XXXIX. Determination of Stability Constants of Some Metal Complexes of N-Phenyl-and N-Ethyl-β-mercaptocinnamamide and Thiodibenzoyl-methane by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents. XXXVIII. Reaction of Platinum (II), Rhodium (III) and Mercury (II) Ion with Monothio-β-diketones and Their Disulfides
- Studies on the Sulfur-containing Chelating Agents. XXXVII. Solvent Effect on Nuclear Magnetic Resonance Spectra of Cobalt (III) Monothioacetylacetonate and Its Brominated Products
- ポジトロン核医学利用専門委員会が成熟技術として認定した放射性薬剤の臨床使用の指針(2009年改定)
- ポジトロン核医学利用専門委員会が成熟技術として認定した放射性薬剤の基準(2009年改定)
- ^In標識アンチセンス核酸による腫瘍イメージングの可能性に関する検討 : 合成,安定性,体内分布
- OP-104 前立腺癌骨転移診断における18F-PETの臨床的有用性に関する検討(第95回日本泌尿器科学会総会)
- 444 肺野型サルコイドーシスにおけるdua-time point FDG-PET imagingの有用性の検討(膠原病と類縁疾患1,一般演題(デジタルポスター),第57回日本アレルギー学会秋季学術大会)
- 薬による放射性医薬品の体内挙動の変化について
- サイクロトロン核医学利用専門委員会が成熟技術として認定した放射性薬剤の基準と臨床使用の指針(1994年改定)
- ラジオアイソトープ断層画像法によるラット脳および心筋血流量と神経レセプター機能に与える薬物の影響評価
- 癌性疼痛緩和を目的とする^Re標識1-hydroxyethylidene-1,1-diphosphonateの作成とマウス体内動態の検討
- Noninvasive Measurement of Cerebral Blood Flow and Glucose Metabolic Rate in the Rat with High-Resolution Animal Positron Emission Tomography (PET) : A Novel in Vivo Approach for Assessing Drug Action in the Brains of Small Animals
- Radioiodinated N-(2-Aminoethyl)-2-chloro-4-iodobenzamide : A New Ligand for Monoamine Oxidase B Studies with Single Photon Emission Computed Tomography
- Differential Aging Pattern of Cerebral Accumulation of Radiolabeled Glucose and Amino Acid in the Senescence Accelerated Mouse (SAM), a New Model for the Study of Memory Impairment
- Synthesis and Characterization of ^C-Labeled Fluoroclorgyline : A Monoamine Oxidase A Specific Inhibitor for Positron Emission Tomography
- Synthesis and Evaluation of Iodinated Benzamide Derivatives as Selective and Reversible Monoamine Oxidase B Inhibitors
- Synthesis of (S)-N-[Methyl-^C]nicotine and Its Regional Distribution in the Mouse Brain : A Potential Tracer for Visualization of Brain Nicotinic Receptors by Positron Emission Tomography
- 拡張DOG関数を用いたオートラジオグラフィーの画質改善(Poster2)
- 蛋白質放射性医薬品の肝滞留性の評価に有用な薬物速度論的モデル
- Ga-Labeling of Immunoglobulin G with High Specific Radioactivity
- 「ポジトロン核医学利用専門委員会が成熟技術として認定した放射性薬剤の基準」の今後のあり方について : 「研究」と「診療」の境界を結ぶ
- 頸動脈病変は脳循環にどのような影響を与えるか-PET による retrospective な検討-
- Cu-ATSM, an Intracellular-Accessible Superoxide Dismutase (SOD)-Like Copper Complex : Evaluation in an Ischemia-Reperfusion Injury Model
- Mitochondria-Selective Reduction of ^Cu-Pyruvaldehyde Bis(N^4-methylthiosemicarbazone) (^Cu-PTSM) in the Murine Brain; a Novel Radiopharmaceutical for Brain Positron Emission Tomography (PET) Imaging
- 脳卒中治療に関連した分子プローブの開発と臨床応用の可能性
- Application of [^I] (S)-5-Iodonicotine, a New Radioiodinated Ligand, in the Assay of Nicotinic Acetylcholine Receptor Binding in the Brain
- An Approach for Assaying Benzodiazepine Receptor Binding with Radioiodinated Ligand : ^I-Labeled Diazepam Derivative
- Evaluation of N-Alkyl Derivatives of Radioiodinated Spiperone as Radioligands for in Vivo Dopamine D_2 Receptor Studies : Effects of Lipophilicity and Receptor Affinity on the in Vivo Biodistribution
- A Synthetic Method Suitable for the Rapid Preparation of ^N-Labeled Dermorphin Analogue, H-Try-D-Met(O)-Phe-Gly-NH_2 (SD-62)
- γ線放出核種による薬物の体内分布の検討
- PET分子イメージングとDDS
- 概論, 機器
- 医薬品開発における分子イメージングの利用
- Introduction to "Molecular Imaging"
- 分子イメージングの現状と展望
- 生体画像情報処理技術とDDS機能評価
- 放射性同位元素の医学利用 : 診断から治療へ
- 放射性医薬品 SPECT
- 50を切る
- 技術賞受賞 新規抗てんかん薬ゾニサミドの開発研究
- 第5回21世紀の薬学を探る京都シンポジウム
- 放射性医薬品 : 核医学画像診断薬
- 現場からの発言(薬学におけるFIの教育と研究の課題)
- ^Tc標識化合物の標識化学とその品質管理(核医学分科会 教育講演)
- Investigation of Radiopharmaceuticals for Pancreatic Imaging : Accumulation of Amines in the Pancreas
- Cu-Pyruvaldehyde-bis (N^4-methylthiosemicarbazone) (Cu-PTSM), a Metal Complex with Selective NADH-Dependent Reduction by Complex I in Brain Mitochondria : A Potential Radiopharmaceutical for Mitochondria-Functional Imaging with Positron Emission Tomograph
- 一過性脳障害における, 脳内末梢性ベンゾジアゼピンレセプターの発現とその意義
- Studies on the Sulfur-containing Chelating Agents. XXIV. Acid Dissociation and Chelate Formation of Penicillamine
- Reduction of Selenocystamine by Thiols
- Studies on the Sulfur-containing Chelating Agents. XXXI. Catalytic Effect of Copper (II) Ion to Formation of Mixed Disulfide
- Syntheses of Metal Complexes of Selenocysteamine
- Syntheses of Related Compounds of Selenocysteamine and Their Complex Formation with Metal Ions
- Studies on the Sulfur-containing Chelating Agents. XXIX. Reaction of Cysteamine and Its Related Compounds with Copper
- Metal Complexes of Selenocysteamine
- Acid Dissociation of Selenocysteamine (2-Aminoethaneselenol)
- 医学・薬学分野から見たRI・放射線利用の将来展望
- Studies on the Sulfur-containing Chelating Agents. XXXVI. Reaction of Palladium Monothioacetylacetonate with Sulfide Ion and Its Application for Determination of Sulfide Ion
- Studies on the Sulfur-containing Chelating Agents. XXXII. The Reaction of Palladium (II) Ion with Monothio-β-diketones and Their Disulfides
- Studies on the Sulfur-containing Chelating Agents. XXIII. Some Investigations on the Quasiaromaticity of Cobalt (III) Thio-β-diketonates by the Spectroscopic Methods
- Studies on the Sulfur-containing Chelating Agents. XXII. Some Metal Chelates of Thio-β-diketones and Bromination of Cobalt (III) Thio-β-diketonates
- The Metal Chelates of Thio Derivatives of β-Diketones
- The Effect of the Alkaline Earth Salts on the NMR Spectrum of Phenols
- Studies on the Sulfur-containing Chelating Agents. XIV. Syntheses of β-Mercaptocinnamamides and their Structures.
- Development of Glycoside-Bound Radiopharmaceuticals : Novel Radioiodination Method for Digoxin
- 薬学における放射科学の現状と将来展望
- Characterization of Technetium-99m Complexes of Pentane-2,4-dione Bis(N-methylthiosemicarbazone)
- Stable and Lipophilic Technetium-99m Dithiosemicarbazone Complexes with 5-6-5 Membered Chelate Ring Structure
- ^Cu-Labeling of Human Serum Albumin-Dithiosemicarbazone (HSA-DTS) Conjugate for Regional Plasma Volume Measurement : Application of New ^Zn/^Cu Generator System
- 5. 放射性医薬品
- 核医学における薬学の役割
- 再生医療における細胞追跡
- Studies on the Sulfur-containing Chelating Agents. XXXIV. Determination of Stability Constant of Mercury Complex of Monothiodibenzoylmethane and Monothiothenoyltrifluoroacetone by Solvent Extraction Method
- ラベリング法-7-医療における放射性同位元素標識化合物の利用(セミナ-室)
- 核医学画像診断薬剤 (微量金属の生体作用--金属イオンの生理機能と薬理作用解明をめざして) -- (疾患と微量金属)
- 金属の利用によるがんの診断と化学療法 (Bioinorganic Chemistry-2-) -- (実際問題への展開)
- Studies on the Sulfur-containing Chelating Agents. XXXV. Determination of Acid Dissociation Constants of N-Phenyl- and N-Ethyl-β-mercaptocin-namamide and Thiodibenzoylmethane by Solvent Extraction Method
- Formamidinesulfinic Acid as a Reducing Agent. I.
- ペーパークロマトグラフ分離による無機水銀および有機水銀の同位体希釈分析 : イオウを含むキレート試薬に関する研究(第19報)
- Studies on the Sulfur-containing Chelating Agents.XV.Thioxo-thioenol Tautomerism in Ethyl β-Mercaptothiocinnamates and β-Mercaptocinnamamides
- Studies on the Sulfurcontaining Chelating Agents. XIII. Syntheses of Esters of β-Mercaptothiocinnamic Acid and their Structures.
- Studies on the Sulfurcontaining Chelating Agents. XII. Relationship between Chelating Ability and Chemical Structure of Ligand. (2).
- Studies on the Sulfurcontaining Chelating Agents. XI. Relationship between Chelating Ability and Chemical Structure of Ligand. (1).
- Studies on Sulfur-containing Chelating Agents. X. Mercapto-acid Amides and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. IX. Syntheses of Alkyl or Aryl o-Mercaptophenyl Ketones, Esters of o-Mercaptobenzoic Acid, S-Esters of o-Mercaptothiobenzoic Acid, and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. VIII. Syntheses of α, β-Unsaturated β-Mercapto-acid Esters and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. VII. Syntheses of β-Mercaptothiolic Acid Esters and their Metal Chelates.
- Studies on the Sulfur-containing Chelating Agents. VI. Syntheses of β-Mercapto-acid Esters and their Copper and Nickel Chelates.
- Studies on the Sulfur-containing Chelating Agents. V. : Syntheses of β-Mercapto-acid Esters, and their Copper and Nickel Chelates. (1).
- β-メルカプトヒドロ桂皮酸アニリド,β-メルカプト桂皮酸アニリドのニッケル,コバルトの比色定量試薬としての応用
- チオジベンゾイルメタンを抽出キレート剤とする水銀の同位体希釈分析
- ペニシラミンによる有機水銀,無機水銀,鉛,カドミウムおよびニッケルの放射滴定
- β-メルカプトアクリル酸,β-メルカプトクロトン酸の合成とそのチウロニウム塩のニッケル,コバルトの比色定量試薬としての応用