Cu-ATSM, an Intracellular-Accessible Superoxide Dismutase (SOD)-Like Copper Complex : Evaluation in an Ischemia-Reperfusion Injury Model
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概要
- 論文の詳細を見る
We have reported a stable superoxide dismutase (SOD)-like copper complex, Cu-ATSM, which shows high membrane permeability and distribution to the brain or heart. In this study, we evaluated the protective effects of Cu-ATSM on superoxide-mediated tissue damage caused by ischemia-reperfusion using an isolated perfused rat heart model. Lipid peroxidation levels in the Cu-ATSM treated group were lower than those in the non-treated group. Furthermore, released creatine phosphokinase into the perfusate, a marker of tissue damage, was reduced by Cu-ATSM treatment. These results indicated the possibility of Cu-ATSM being an effective SOD-like drug for the treatment of superoxide-mediated damage, such as ischemia-reperfusion injury.
- 社団法人日本薬学会の論文
- 1994-05-15
著者
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藤林 靖久
福井大学高工ネルギー医学研究センター
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横山 陽
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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横山 陽
京都大・薬・病態機能分析
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和田 耕一
Faculty of Pharmaceutical Sciences, Kyoto University
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藤林 靖久
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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和田 耕一
Faculty Of Pharmaceutical Sciences Kyoto University
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和田 耕一
Department of Radiopharmaceutical Chemistry Faculty of Pharmaceutical Sciences, Kyoto University
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田嶋 尚之
Department of Radiopharmaceutical Chemistry Faculty of Pharmaceutical Sciences, Kyoto University
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田嶋 尚之
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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