Development of Glycoside-Bound Radiopharmaceuticals : Novel Radioiodination Method for Digoxin
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概要
- 論文の詳細を見る
We combined 2-hydroxy-3-methylbenzoylhydrazide (HMBH) with glycosides as a novel method for the radioiodination of physiologically active glycosides. This method was tested using digoxin, which is one of the cardiac glycosides. A digoxin-HMBH conjugate was synthesized by periodate cleavage of the third sugar ring, and was readily radiolabelled with Na[^<125>I] by the chloramine-T method. ^<125>I labelled digoxin-HMBH conjugate retained Na^+, K^+-ATPase binding in vivo and in vitro, and also retained immunoreactivity to an anti-digoxin antibody. Thus, this ^<125>I labelled digoxin-HMBH conjugate represents a potential radiopharmaceutical for Na^+, K^+-ATPase imaging, as well as for the radioimmunoassay of digoxin.
- 公益社団法人日本薬学会の論文
- 1994-01-15
著者
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藤林 靖久
福井大学高工ネルギー医学研究センター
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横山 陽
京都大学薬学部
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横山 陽
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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小西 淳二
Department of Nuclear Medicine, School of Medicine, Kyoto University
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藤林 靖久
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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横山 陽
京大
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土手 宣人
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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谷内 英之
Department of Radiopharmaceutical Chemistry Faculty of Pharmaceutical Sciences, Kyoto University
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小西 淳二
Department Of Nuclear Medicine And Diagnostic Imaging Kyoto University Graduate School Of Medicine
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谷内 秀之
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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飯島 直子
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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竹村 泰隆
Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University
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竹村 泰隆
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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