Studies on the Sulfur-containing Chelating Agents. XLV. Kinetics of Ligand Exchange Reaction of Mercury-Monothiodibenzoylmethane Complex with Some Thiol Compounds by Stripping Solvent Extraction
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概要
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The kinetics of ligand exchange reaction of mercury-monothiodibenzoylmethane complex with various thiol compounds (THIOL) is studied by stripping solvent extraction method. Mercaptoethylamine (MEA), penicillamine (Pen), cysteine (Cys), glutathione (GSH), α-mercaptopropionic acid (α-MPA), β-mercaptopropionic acid (β-MPA), N-acetylcysteine (NAC) and thiomalic acid (TMA) are used as thiol compounds. The reaction rate is determined by the measurements of the radioactivity of ^<203>Hg in the aqueous phase. Thiol compounds were classified into two types based on their reaction rates, and in these reactions the formations of the mixed ligand complexes are considered to be involved. The observed reaction rates at physiological pH are distinctly higher in the thiols with amino group than in other thiols.
- 社団法人日本薬学会の論文
- 1975-08-25
著者
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田中 久
Faculty of Pharmaceutical Sciences, Kyoto University
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横山 陽
Faculty of Pharmaceutical Sciences, Kyoto University
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中西 信子
Faculty of Pharmaceutical Sciences, Kyoto University
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横山 陽
Department Of Radiopharmaceutical Chemistry Faculty Of Pharmaceutical Sciences Kyoto University
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中西 信子
Faculty Of Pharmaceutical Sciences Kyoto University
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