Studies on Imidazole Derivatives as Chelating Agents. III. Syntheses of Schiff Bases and 4 (5)-Aminomethyl Derivatives and Their Reactions with Metal Ions.

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The Schiff bases from 4 (5)-imidazolecarboxaldehyde and aromatic amines (type [A]), those from 4 (5)-amino-5 (4)-methylimidazole and aromatic aldehydes (type [B]), and 4 (5)-aminomethylimidazoles (type [C]) were prepared. The compounds [A] and [C] react with Fe (III), Cu (II), Pd (II), Pt (IV), Au (III), ect. to give green〜brown colors, whereas the compounds [B] give only faint colors with Cu (II), Pt (IV), and Au (III). The copper chelates of type Cu (ligand)_2Br_2,where the ligands are the compounds [A] and [C], were isolated, and the binding site of the imidazole nucleus was determined to be the pyridine nitrogen by comparing the IR spectra with those of the deuteration products and of the copper chelate of type Cu (ligand)_2. The reactivities of the compounds [A] and [C] suggest that they behave as bidentate ligands.
社団法人日本薬学会の論文
1967-10-25