Isolation and Structural Investigation of the Chromophore in the Fujiwara Reaction as Applied to Chloramphenicol
スポンサーリンク
概要
- 論文の詳細を見る
The structure of a red chromogen which is produced by applying the Fujiwara reaction to chloramphenicol was determined by means of NMR, mass spectroscopy and reasonance Raman spectroscopy. The red product was identified as 5-hydroxymethyl-4-(4-nitrobenzeno)-2,3-pyrrolidindione. This compound is different from the nitrogenated polyene which is produced in the Fujiwara reaction applied to such gem-trichloro compounds as chloroform and benzotrichloride.
- 社団法人日本薬学会の論文
- 1983-08-25
著者
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
黒田 義弘
Faculty of Pharmaceutical Sciences, Kyoto University, Yoshida
-
奥村 一夫
Research Institute, Tokobo, Co., Ltd.,
-
奥村 一夫
Faculty of Pharmaceutical Sciences, Kyoto University
-
奥村 一夫
Research Institute Tokobo Co. Ltd.
-
黒田 義弘
Faculty Of Pharmaceutical Sciences Kyoto University
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
関連論文
- On the Retention Index
- Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man
- New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time
- High Performance Liquid Chromatographic Determination and Pharmacokinetic Investigation of Amino-penicillins and Their Metabolites in Man
- Isolation and Structural Investigation of the Fluorescent Degradation Products of Ampicillin
- Comparative Pharmacokinetics of Metabolism and Urinary Excretion of Isoxazolylpenicillins in Man
- Pharmacokinetic Studies of the Urinary Excretion of Clavulanic Acid in Man
- High Performance Liquid Chromatographic Analysis and Pharmacokinetic Investigation of Oxacillin and Its Metabolites in Man
- Evaluation of Effect of Food Ingestion on Bioavailability of Cephalexin by Moment Analysis
- ^1H-Nuclear Magnetic Resonance Studies on Interaction between 4-[4-(N, N-Dimethylcarbamoylme- thoxycarbonymethyl)phenoxycarbonylphenyl]guanidinium Methanesulfonate and Trypsin
- Pharmacokinetics in Chimpanzees of Recombinant Human Tissue-Type Plasminogen Activator Produced in Mouse C127 and Chinese Hamster Ovary Cells
- Reaction Products of Sulbactam with Pyrazole, 1,2,4-Triazole and Imidazole : High-Performance Liquid Chromatographic Behavior and Structural Investigation
- Degradation Kinetics of Sodium Sulbactam in Aqueous Solutions
- Alkaline Degradation of Sulbactam
- Fast Atom Bombardment Mass Spectrometry of Isoxazolylpenicillins and Their Metabolites in Man
- Degradation of Clavulanic Acid in Aqueous Alkaline Solution : Isolation and Structural Investigation of Degradation Products
- Structure Confirmation of Active Metabolite of Dicloxacillin in Man by Nuclear Magnetic Resonance Spectroscopy
- Sulbactam : Alkaline Degradation and Determination by High-Performance Liquid Chromatography
- Determination of Rate Constants for Formation and Decomposition of Color Products in the Fujiwara Reaction Using Benzotrichloride
- Alkaline Degradation of Clavulanic Acid and High Performance Liquid Chromatographic Determination by Post-Column Alkaline Degradation
- Isolation and Structural Investigation of the Chromophore in the Fujiwara Reaction as Applied to Chloramphenicol
- DEGRADATION OF CLAVULANIC ACID IN AQUEOUS ALKALINE SOLUTION
- The Fujiwara Reaction : Isolation and Structural Investigation of the Reaction Product from Chloroform
- クラブラン酸のHPLC分析ならびにBRL25000(Clavulanic acid-Amoxicillin)のヒト尿排泄に関する薬物速度論的考察 (BRL25000(Clavulanic acid-Amoxicillin))
- Stability of Clavulanic Acid in Aqueous Solutions
- Simultaneous Determination of the Free and Total Carbamazepine Concentrations in Human Plasma by High-Performance Frontal Analysis Using an Internal-Surface Reversed-Phase Silica Support
- Studies on Imidazole Derivatives as Chelating Agents. III. Syntheses of Schiff Bases and 4 (5)-Aminomethyl Derivatives and Their Reactions with Metal Ions.
- Studies on Imidazole Derivatives as Chelating Agents. II. Spectrophotometric and Potentiometric Investigations of Acid-base Equilibria of Azoimidazoles
- Studies on Imidazole Derivatives as Chelating Agents. I. Syntheses of Azoimidazoles and Their Reactions with Metal Ions
- Characteristics of a Lorentzian to Gaussian Transformation Function as a Weighting Function in Processing the Two-Dimensional Nuclear Magnetic Resonance Spectrum of a Drug-Phosphatidylcholine Vesicles Solution
- Variations in Average Electronic Excitation Energy as the Cause of ^C Nuclear Magnetic Resonance Protonation Shifts of 4-Aminoazobenzene
- Specificity of Human Natural Antibody to Recombinant Tissue-Type Plasminogen Activator (t-PA) Expressed in Mouse C127 Cells
- Studies on the Metabolism of Sulfadiazine. I. On the Separation and Identification of Excrements in Human Urine after its Oral Administration.
- Infrared Spectra of Sulfonamide Derivatives. I. Pyridine, Thiazole, and Pyrimidine Derivatives.
- Studies on Benzothiazole Derivatives as Chelating Agents. V. Fluorescence of Benzothiazole Derivatives and Their Zinc Chelates
- Studies on Benzothiazole Derivatives as Chelating Agents. IV. Coordination to Divalent Metal Ions
- Studies on Benzothiazole Derivatives as Chelating Agents. III. Acid-base Equilibria and Chelate Formation with Metal Ions
- Studies on Benzothiazole Derivatives as Chelating Agents. II. The Fluorometric Determination of Zinc with N-Salicylidene-4-aminobenzothiazole
- Studies on Benzothiazole Derivatives as Chelating Agents. I. Syntheses of Benzothiazole Derivatives and Their Reactions with Metal Ions
- Infrared Spectra of Sulfonamide Derivatives. II. Thiophene, Thiadiazole, and Isoxazole Derivatives
- Determination of Surface-active Agents. VIII. Infrared Determination of the Proportion of Ethylene Oxide and Propylene Oxide in Pluronic
- Interaction between Dibucaine and Pig Erythrocyte Membranes as Studied by NOESY Experiments in ^1H-NMR Spectroscopy. Which Form of Dibucaine Interacts More Strongly, Cationic or Uncharged?
- Interactions between Local Anesthetic Dibucaine and Pig Erythrocyte Membranes as Studied by Proton and Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy
- Structural Investigation of New Metabolites of Aminopenicillins excreted in Human Urine
- Studies on the Metabolism of Sulfadimethoxine. II. Determinations of Metabolites in Human and Rabbit Urine after Oral Administration of Sulfadimethoxine.
- GC-MS Identification of Active Metabolite of Oxacillin in Man
- Mechanism of Color Reaction of Aromatic Secondary and Tertiary Amines with Quinonedichlorodiimide
- キノンジクロルジイミドによるキノホルムの定量法
- Studies on the Metabolism of Sulfadiazine. II. Quantitative Separation of Excrements in the Human Urine after Administration of Sulfadiazine
- セファロスポリンおよびその代謝物のHPLC分析 (バイオメディカルクロマトグラフィ--2-) -- (薬物および薬物代謝のクロマトグラフィ-)
- A New Metabolite of Ampicillin in Man
- Studies on the Metabolism of Sulfathiazole. IV. A New Sulfathiazole-glucuronic Acid Conjugate in the Human Urine.
- Infrared Spectra of α-Bromoacylureas and Their N, N'-Deuterated Compounds
- Studies on the Metabolism of Sulfadimethoxine. I. On the Excreted substance in the Human Urine after Oral Administration of Sulfadimethoxine
- Determination of Surfaceactive Agents. VII. Differential Determination of Cationics and Nonionics in Mixture.
- Color Reaction Mechanism of Chinoform by Quinonedichlorodiimide
- Colorimetric Determination and Detection of Tertiary Amines with cis-Aconitic Anhydride
- キノンジクロルジイミドによるスルピリンのけい光定量法
- キノンジクロルジイミドによるアミン類の呈色反応および定量法
- 二級アミンの比色定量法
- Determination of Surface-active Agents. VI. On the Composition of Nonionics-Barium-Tetraphenylborate Complex.
- Determination of Surfaceactive Agents. V. Volumetric Determination of Ethylene Oxide Content in Nonionic Surface-active Agent.
- Determination of Surface-active Agent. III. Volumetric Determination of Anionic Surface-active Agent using Neutral Red as an Indicator.
- Volumetric Determination of Surfaceactive Quaternary Ammonium Salts using Marme's Reagent.