New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time
スポンサーリンク
概要
- 論文の詳細を見る
A new model-independent method is proposed for evaluating the in vitro dissolution time and disintegration time of solid dosage forms. The mean in vitro dissolution time (in vitro MDT) is defined as the first moment of the dissolution rate-time curve, that is, MDT=∫^∞_0t (dm/dt) dt/∫^∞_0 (dm/dt) dt, where dm/dt is the dissolution rate of a drug at time t. The mean in vitro disintegration time (in vitro MDIT) is defined by subtraction of MDT for drug powder from that for its tablet or capsule. The MDT is correlated with the parameters of several dissolution models.
- 社団法人日本薬学会の論文
- 1982-03-25
著者
-
谷川原 祐介
第一薬品工業
-
谷川原 祐介
Faculty Of Pharmaceutical Sciences Kyoto University
-
宇野 豊三
Faculty of Pharmaceutical Sciences, Kyoto University
-
山岡 清
Faculty of Pharmaceutical Sciences, Kyoto University
-
中川 照真
Faculty of Pharmaceutical Sciences, Kyoto University
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
中川 照眞
京都大学 薬研究
-
山岡 清
京都大学薬学部
-
山岡 清
Faculty Of Pharmaceutical Sciences Kyoto University
-
中川 照真
京都大学薬学部
-
中川 照眞
京都大学薬学部
-
中川 照眞
京大 大学院薬学研究科
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
-
宇野 豊三
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
関連論文
- On the Retention Index
- Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man
- New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time
- High Performance Liquid Chromatographic Determination and Pharmacokinetic Investigation of Amino-penicillins and Their Metabolites in Man
- Isolation and Structural Investigation of the Fluorescent Degradation Products of Ampicillin
- Effect of Temperature in Perfusate on Local Hepatic Disposition of BOF-4272,a New Xanthine Oxidase Inhibitor
- Local Disposition of a New Xanthine Oxidase/Xanthine Dehydrogenase Inhibitor, BOF-4272,in Rat Liver
- 薬物体内動態評価のルーチン化とその解析プログラムの開発に関する研究
- T-588のラットにおける非線形性の検討 - 門脈-静脈血漿中濃度差に基づく初回通過効果の分離評価 -
- Influence of Laparotomy on Disposition Kinetics of Diclofenac in CCl_4-Intoxicated Rats
- 薬物動態と高速ラプラス逆変換(FILT)
- Microsoft Excel^【○!R】で利用可能なモーメント解析プログラムMOMENT (EXCEL)
- マイクロソフト Excel におけるモーメント自動計算プログラムの開発
- 短期2回投与による門脈血-体循環血薬物濃度差法を用いた消化管吸収動態及び肝局所動態への pentobarbital の影響に関する検討
- 門脈-体循環血薬物濃度差(短期2回投与)法による 5-fluorouracil の消化管吸収及び肝消失動態の同時評価
- 局所動態解析プログラム MULTI(FEM)による 5-Fluorouracil の飽和型肝局所動態の定量的評価
- 短期2回投与による門脈血-体循環血薬物濃度差(P-S difference)法における採血ポイントの最適化に関する検討
- 肝局所動態解析における非線形連続攪拌槽モデルの検討
- 門脈-静脈薬物濃度差を利用した覚醒時ラットにおけるレボフロキサシン初回通過効果の定量的評価
- フマル酸セモチアジル(SD-3211)およびその光学異性体SD-3212の立体選択的肝局所動態
- Recirculatory Moment Analysis of Drugs in Man : Estimation of Extraction Ratio and Mean Cycle Time for Single Systemic and Pulmonary Circulation
- Comparative Pharmacokinetics of Metabolism and Urinary Excretion of Isoxazolylpenicillins in Man
- Pharmacokinetic Studies of the Urinary Excretion of Clavulanic Acid in Man
- High Performance Liquid Chromatographic Analysis and Pharmacokinetic Investigation of Oxacillin and Its Metabolites in Man
- Evaluation of Effect of Food Ingestion on Bioavailability of Cephalexin by Moment Analysis
- 線型ガスクロマトグラフィーにおける直列カラムのモーメントベクトルの加成性
- キャピラリー電気泳動法による目薬の成分分析
- ミセル動電クロマトグラフィ-の生薬分析への応用-4-市販センノサイドA標準品の純度について
- ミセル動電クロマトグラフィ-の生薬分析への応用-3-人参中のginsenoside類の分離
- ミセル動電クロマトグラフィ-の生薬分析への応用-2-漢方製剤中のglycyrrhizinとpaeoniflorinの同時定量
- ミセル動電クロマトグラフィ-の生薬分析への応用-1-漢方製剤中のglycyrrhizinの定量
- ビスムチオール-IIスルホン酸担持イオン交換樹脂を充てんした微量フローカラムを用いるセレンの予備濃縮(超微量分析のための前処理と予備濃縮)
- Improved Flow Injection Analysis (FIA) Method for Determining Selenium in Biological Samples, and the Effect of Captopril Administration on Selenium Levels and Glutathione Peroxidase Activity in Rat
- Development of Effective Cross-Linking Method for Bioactive Substance : Enzyme Immobilization Using Glutaraldehyde Oligomers
- Effect of Protein Binding on High Performance Liquid Chromatography Analysis of Drugs with an Internal-Surface Reversed-Phase Silica Column
- A Nonlinear Least Squares Program, MULTI(FILT), Based on Fast Inverse Laplace Transform for Microcomputers
- Electrokinetic Chromatography for Drug Analysis. Separation and Determination of Cefpiramide in Human Plasma
- Determination of Free Drug in Protein Binding Equilibrium by High-Performance Frontal Analysis Using Internal-Surface Reversed-Phase Silica Support
- Polymerization Reaction in Aqueous Solution of Glutaraldehyde Containing Trioxane-Type Oligomers under Sterilizing Conditins
- ANALYSIS OF WARFARIN-ALBUMIN BINDING BY HPLC WITH INTERNAL-SURFACE REVERSED-PHASE SILICA COLUMN
- SEPARATION AND DETERMINATION OF CEFPIRANIDE IN HUMAN PLASMA BY ELECTROKINETIC CHROMATOGRAPHY WITH A MICELLAR SOLUTION AND AN OPEN TUBULAR-FUSED SILICA CAPILLARY
- Isolation and Identification of New Oligomers in Aqueous Solution of Glutaraldehyde(Analytical,Chemical)
- Effect of Probenecid on Disposition of Cefpiramide in Rat. : The Application of Population Pharmacokinetics(Pharmaceutical)
- Automated System of Dissolution Testing with Data Input through RS-232C Interface of a Personal Computer
- Reaction Products of Sulbactam with Pyrazole, 1,2,4-Triazole and Imidazole : High-Performance Liquid Chromatographic Behavior and Structural Investigation
- Degradation Kinetics of Sodium Sulbactam in Aqueous Solutions
- Alkaline Degradation of Sulbactam
- Fast Atom Bombardment Mass Spectrometry of Isoxazolylpenicillins and Their Metabolites in Man
- Degradation of Clavulanic Acid in Aqueous Alkaline Solution : Isolation and Structural Investigation of Degradation Products
- Structure Confirmation of Active Metabolite of Dicloxacillin in Man by Nuclear Magnetic Resonance Spectroscopy
- Sulbactam : Alkaline Degradation and Determination by High-Performance Liquid Chromatography
- Determination of Rate Constants for Formation and Decomposition of Color Products in the Fujiwara Reaction Using Benzotrichloride
- Alkaline Degradation of Clavulanic Acid and High Performance Liquid Chromatographic Determination by Post-Column Alkaline Degradation
- Isolation and Structural Investigation of the Chromophore in the Fujiwara Reaction as Applied to Chloramphenicol
- DEGRADATION OF CLAVULANIC ACID IN AQUEOUS ALKALINE SOLUTION
- The Fujiwara Reaction : Isolation and Structural Investigation of the Reaction Product from Chloroform
- クラブラン酸のHPLC分析ならびにBRL25000(Clavulanic acid-Amoxicillin)のヒト尿排泄に関する薬物速度論的考察 (BRL25000(Clavulanic acid-Amoxicillin))
- Stability of Clavulanic Acid in Aqueous Solutions
- Studies on Imidazole Derivatives as Chelating Agents. III. Syntheses of Schiff Bases and 4 (5)-Aminomethyl Derivatives and Their Reactions with Metal Ions.
- Studies on Imidazole Derivatives as Chelating Agents. II. Spectrophotometric and Potentiometric Investigations of Acid-base Equilibria of Azoimidazoles
- Studies on Imidazole Derivatives as Chelating Agents. I. Syntheses of Azoimidazoles and Their Reactions with Metal Ions
- 奨励賞受賞 萩中 淳氏の業績
- 第二のルネサンス
- Studies on the Metabolism of Sulfadiazine. I. On the Separation and Identification of Excrements in Human Urine after its Oral Administration.
- Infrared Spectra of Sulfonamide Derivatives. I. Pyridine, Thiazole, and Pyrimidine Derivatives.
- Studies on Benzothiazole Derivatives as Chelating Agents. V. Fluorescence of Benzothiazole Derivatives and Their Zinc Chelates
- Studies on Benzothiazole Derivatives as Chelating Agents. IV. Coordination to Divalent Metal Ions
- Studies on Benzothiazole Derivatives as Chelating Agents. III. Acid-base Equilibria and Chelate Formation with Metal Ions
- Studies on Benzothiazole Derivatives as Chelating Agents. II. The Fluorometric Determination of Zinc with N-Salicylidene-4-aminobenzothiazole
- Studies on Benzothiazole Derivatives as Chelating Agents. I. Syntheses of Benzothiazole Derivatives and Their Reactions with Metal Ions
- Infrared Spectra of Sulfonamide Derivatives. II. Thiophene, Thiadiazole, and Isoxazole Derivatives
- Determination of Surface-active Agents. VIII. Infrared Determination of the Proportion of Ethylene Oxide and Propylene Oxide in Pluronic
- Structural Investigation of New Metabolites of Aminopenicillins excreted in Human Urine
- Studies on the Metabolism of Sulfadimethoxine. II. Determinations of Metabolites in Human and Rabbit Urine after Oral Administration of Sulfadimethoxine.
- GC-MS Identification of Active Metabolite of Oxacillin in Man
- Mechanism of Color Reaction of Aromatic Secondary and Tertiary Amines with Quinonedichlorodiimide
- Studies on the Metabolism of Sulfadiazine. II. Quantitative Separation of Excrements in the Human Urine after Administration of Sulfadiazine
- セファロスポリンおよびその代謝物のHPLC分析 (バイオメディカルクロマトグラフィ--2-) -- (薬物および薬物代謝のクロマトグラフィ-)
- A New Metabolite of Ampicillin in Man
- Studies on the Metabolism of Sulfathiazole. IV. A New Sulfathiazole-glucuronic Acid Conjugate in the Human Urine.
- Infrared Spectra of α-Bromoacylureas and Their N, N'-Deuterated Compounds
- Studies on the Metabolism of Sulfadimethoxine. I. On the Excreted substance in the Human Urine after Oral Administration of Sulfadimethoxine
- Determination of Surfaceactive Agents. VII. Differential Determination of Cationics and Nonionics in Mixture.
- Color Reaction Mechanism of Chinoform by Quinonedichlorodiimide
- Colorimetric Determination and Detection of Tertiary Amines with cis-Aconitic Anhydride
- Determination of Surface-active Agents. VI. On the Composition of Nonionics-Barium-Tetraphenylborate Complex.
- Determination of Surfaceactive Agents. V. Volumetric Determination of Ethylene Oxide Content in Nonionic Surface-active Agent.
- Determination of Surface-active Agent. III. Volumetric Determination of Anionic Surface-active Agent using Neutral Red as an Indicator.
- Volumetric Determination of Surfaceactive Quaternary Ammonium Salts using Marme's Reagent.
- 界面活性剤の分析 (II) : 親油性基の分析 (その2) ガスクロマトグラフィーを用いる分析法 (2)
- 界面活性剤の分析 (II) : 親油性基の分析 (その3) ガスクロマトグラフィー以外の方法を用いる分析
- 界面活性剤の分析 (II) : 親油性基の分析 (その1) ガスクロマトグラフィーを用いる分析法 (1)
- ミセル動電クロマトグラフィーの生薬分析への応用(第4報) : 市販センノサイドA標準品の純度について
- ミセル動電クロマトグラフィーの生薬分析への応用(第3報) : 人参中のginsenoside類の分離
- ミセル動電クロマトグラフィーの生薬分析への応用(第2報) : 漢方製剤中のglycyrrhizinとpaeoniflorinの同時定量
- ベンザルコニウム塩の熱分解ガスクロマトグラフィー
- アルキルアニリニウム塩の熱分解ガスクロマトグラフィー
- タイトル無し
- タイトル無し
- Clinical pharmacokinetics of valproic acid in children with seizures. Plasma concentration data analysis by the Bayesian method.:Plasma Concentration Data Analysis by the Bayesian Method