Studies on Benzothiazole Derivatives as Chelating Agents. I. Syntheses of Benzothiazole Derivatives and Their Reactions with Metal Ions

概要

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A number of 2-, 4- and 7-substituted benzothiazole derivatives were synthesized to inquire into the relationship between the fluorescence of metal chelates and their structures, and to investigate their applications as analytical reagents. The color and fluorescence reactions of metal ions with these benzothiazole derivatives were investigated by spot tests. On the formation of metal complexes in solution, the color change of 2-substituted derivatives was more remarkable than that of 4- and 7-substituted. As fluorometric reagents for metal ions, however, 4-aminobenzothiazothiazole derivatives were superior to 2-amino and 7-aminobenzole derivatives. 7-Substituted derivatives were inferior in the reactivity with metal ions to 2- and 4-substituted.
公益社団法人日本薬学会の論文
1973-01-25