Studies on the Metabolism of Sulfadimethoxine. I. On the Excreted substance in the Human Urine after Oral Administration of Sulfadimethoxine
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概要
- 論文の詳細を見る
Metabolic products of sulfadimethoxine excreted in human urine were examined and three metabolites were separated. Unchanged sulfadimethoxine and N^4-acetylsulfadimethoxine were confirmed by paper chromatography and electrophoresis. And, the other one was sulfadimethoxine-N-glucuronide, and the methyl acetyl derivative of the glucuronide was confirmed sulfadimethoxine-N^1-methyl-(tri-O-acetyl-β-D-glucopyranosid)uronate-N^4-acetate. Sulfadimethoxine-N-glucuronide found in human urine was decided to be sulfadimethoxine-N^1-β-D-glucopyranoside or its lactone form.
- 公益社団法人日本薬学会の論文
- 1965-03-25
著者
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宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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藤本 昌彦
Osaka Factory Of Sankyo Co. Ltd.
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宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
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久島 諦史朗
Osaka Factory of Sankyo Co., Ltd.
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