Studies on Imidazole Derivatives as Chelating Agents. I. Syntheses of Azoimidazoles and Their Reactions with Metal Ions
スポンサーリンク
概要
- 論文の詳細を見る
As part of the systematic studies on imidazole derivatives as chelating agents, four azoimidazoles having an ortho-hydroxy group, a dimethylamino group, or both groups were prepared from 4(5)-amino-5(4)-methylimidazole as a diazo component and 2-naphthol, p-methoxyphenol, N, N-dimethylaniline, and N, N-dimethyl-m-aminophenol as coupling components : 1-[4(5)-methyl-5(4)-imidazolylazo]-2-naphthol ; 2-[4(5)-methyl-5(4)-imidazolylazo]-4-methoxyphenol ; 4(5)-methyl-5(4)-(p-dimethylaminophenylazo) imidazole ; 3-dimethylamino-6-[4(5)-methyl-5(4)-imidazolylazo] phenol. The reactions of the azo derivatives with various metal ions were studied by spot tests in acid, neutral, and alkaline solutions. All the azo derivatives react with metal ions, such as Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Pd(II) and Pb(II), to give intensely colored chelates which are usually extracted into chloroform or iso-amyl alcohol. These results indicate that the azoimidazoles can be used as metallochromic indicators or as extractants for determinations of metal ions by chelatometric titrations or by solvent extractions.
- 社団法人日本薬学会の論文
- 1966-09-25
著者
-
田中 久
Faculty of Pharmaceutical Sciences, Kyoto University
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
山内 脩
Faculty Of Pharmaceutical Sciences Kyoto University:(present Address)institute Of Chemistry College
-
宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
関連論文
- Distribution of Some Disulfhydryl-Containing Chelating Agents labeled with Indium-113m and Gallium-67 in Mice
- Radioprotective Effect of Ergothioneine on γ-Irradiation of Metmyoglobin : Comparison with Cysteine on Sulfmyoglobin-Formation
- Metal Complexes of Ergothioneine
- Peroxidase-like Catalytic Activity of Anion-Exchange Resins Modified with Metalloporphyrins in the Dye Formation Reaction of N,N-Diethylaniline with 4-Aminoantipyrine by Hydrogen Peroxide(Analytical,Chemical)
- Peroxidase-like Accelerative Activity of Ion-Exchange Resins Modified with Metalloporphyrins in the Dye Formation Reaction of Phenol with 4-Aminoantipyrine by Hydrogen Peroxide(Analytical,Chemical)
- Catalase-like Catalytic Activity of Ion-Exchange Resins Modified with Metalloporphyrins
- Dimethylsulfoxide Clathrates of Metal Complexes of β-Mercaptothiocinnamamide Derivatives
- Synthesis and Properties of Bis (N-methyl-, N-phenyl-β-mercaptothiocinnamamido) palladium (II)
- Synthesis and Properties of N-(2-Methylphenyl)- and N-(2,6-Dimethylphenyl)-β-mercaptothiocinnamamide and Their Palladium (II) Complexes
- A Novel Method of Preparation of Bis (dithiobenzoylacetonato) Zn (II)
- Synthesis and Properties of Bis (N-phenyl-β-mercaptothiocinnamamido) Ni (II)
- Synthesis and Properties of Bis (N-phenyl-β-mercapto-thiocinnamamido) Pd (II)
- Preparation of a New Dithioligand
- Studies on the Sulfur-containing Chelating Agents. XLVI. Hydrolysis of Thio-β-diketones and Related Amides in Acetonitrile-Water Mixture
- Studies on the Sulfur-containing Chelating Agents. XLV. Kinetics of Ligand Exchange Reaction of Mercury-Monothiodibenzoylmethane Complex with Some Thiol Compounds by Stripping Solvent Extraction
- Studies on the Sulfur-containing Chelating Agents. XLIV. Kinetic Study of Ligand Exchange Reaction of Mercury-Aminopolycarboxylate with Monothiodibenzoylmethane by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents. XLIII. The Reaction of Thio-β-diketones and the Related Compounds with Iron (II) in the Presence of Pyridine
- Studies on the Sulfur-containing Chelating Agents. XLII. Solvent Extraction of Nickel (II) and Zinc (II) with N-(p-Substituted phenyl)-β-mercaptocinnamamides
- Studies on the Sulfur-containing Chelating Agents. XXXIX. Determination of Stability Constants of Some Metal Complexes of N-Phenyl-and N-Ethyl-β-mercaptocinnamamide and Thiodibenzoyl-methane by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents. XXXVIII. Reaction of Platinum (II), Rhodium (III) and Mercury (II) Ion with Monothio-β-diketones and Their Disulfides
- Studies on the Sulfur-containing Chelating Agents. XXXVII. Solvent Effect on Nuclear Magnetic Resonance Spectra of Cobalt (III) Monothioacetylacetonate and Its Brominated Products
- On the Retention Index
- Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man
- New Method for the Evaluation of in Vitro Dissolution Time and Disintegration Time
- High Performance Liquid Chromatographic Determination and Pharmacokinetic Investigation of Amino-penicillins and Their Metabolites in Man
- Isolation and Structural Investigation of the Fluorescent Degradation Products of Ampicillin
- Recirculatory Moment Analysis of Drugs in Man : Estimation of Extraction Ratio and Mean Cycle Time for Single Systemic and Pulmonary Circulation
- Comparative Pharmacokinetics of Metabolism and Urinary Excretion of Isoxazolylpenicillins in Man
- Pharmacokinetic Studies of the Urinary Excretion of Clavulanic Acid in Man
- High Performance Liquid Chromatographic Analysis and Pharmacokinetic Investigation of Oxacillin and Its Metabolites in Man
- Evaluation of Effect of Food Ingestion on Bioavailability of Cephalexin by Moment Analysis
- Development of Effective Cross-Linking Method for Bioactive Substance : Enzyme Immobilization Using Glutaraldehyde Oligomers
- Effect of Protein Binding on High Performance Liquid Chromatography Analysis of Drugs with an Internal-Surface Reversed-Phase Silica Column
- A Nonlinear Least Squares Program, MULTI(FILT), Based on Fast Inverse Laplace Transform for Microcomputers
- Electrokinetic Chromatography for Drug Analysis. Separation and Determination of Cefpiramide in Human Plasma
- Determination of Free Drug in Protein Binding Equilibrium by High-Performance Frontal Analysis Using Internal-Surface Reversed-Phase Silica Support
- Polymerization Reaction in Aqueous Solution of Glutaraldehyde Containing Trioxane-Type Oligomers under Sterilizing Conditins
- ANALYSIS OF WARFARIN-ALBUMIN BINDING BY HPLC WITH INTERNAL-SURFACE REVERSED-PHASE SILICA COLUMN
- SEPARATION AND DETERMINATION OF CEFPIRANIDE IN HUMAN PLASMA BY ELECTROKINETIC CHROMATOGRAPHY WITH A MICELLAR SOLUTION AND AN OPEN TUBULAR-FUSED SILICA CAPILLARY
- Isolation and Identification of New Oligomers in Aqueous Solution of Glutaraldehyde(Analytical,Chemical)
- Effect of Probenecid on Disposition of Cefpiramide in Rat. : The Application of Population Pharmacokinetics(Pharmaceutical)
- Automated System of Dissolution Testing with Data Input through RS-232C Interface of a Personal Computer
- Reaction Products of Sulbactam with Pyrazole, 1,2,4-Triazole and Imidazole : High-Performance Liquid Chromatographic Behavior and Structural Investigation
- Degradation Kinetics of Sodium Sulbactam in Aqueous Solutions
- Alkaline Degradation of Sulbactam
- Fast Atom Bombardment Mass Spectrometry of Isoxazolylpenicillins and Their Metabolites in Man
- Degradation of Clavulanic Acid in Aqueous Alkaline Solution : Isolation and Structural Investigation of Degradation Products
- Structure Confirmation of Active Metabolite of Dicloxacillin in Man by Nuclear Magnetic Resonance Spectroscopy
- Sulbactam : Alkaline Degradation and Determination by High-Performance Liquid Chromatography
- Determination of Rate Constants for Formation and Decomposition of Color Products in the Fujiwara Reaction Using Benzotrichloride
- Alkaline Degradation of Clavulanic Acid and High Performance Liquid Chromatographic Determination by Post-Column Alkaline Degradation
- Isolation and Structural Investigation of the Chromophore in the Fujiwara Reaction as Applied to Chloramphenicol
- DEGRADATION OF CLAVULANIC ACID IN AQUEOUS ALKALINE SOLUTION
- The Fujiwara Reaction : Isolation and Structural Investigation of the Reaction Product from Chloroform
- Polynuclear and Mononuclear Complex Formation between Indium (III) and Sulfhydryl-containing Bidentate Ligands
- Solution Equilibria and Structures of Disulfhydryl-containing Peptide-Indium (III) and Gallium (III) Complex Species
- Hydroxylation of Acetanilide by Iron-Sulfur and Nickel-Sulfur Complex Systems
- Interaction of Albumin, Transferrin, and Human Serum with Indium-113 m Complexes of Ethylenediaminetetraacetic Acid, Penicillamine, and Related Compounds
- Proton Magnetic Resonance Study of Indium (III) and Gallium (III) Binding by Adjacent and Separated Disulfhydryl-Containing Peptides
- Spectroscopic and Catalytic Properties of Penicillamine-Molybdenum Complexes
- Effect of Inorganic Sulfur and Selenium on O_2-Uptake and Aniline Hydroxylation by Dithiothreitol-Iron Complex in Comparison with Adrenodoxin and Se-Adrenodoxin
- Studies on the Sulfur-containing Chelating Agents. XXXIII. Interaction of Penicillamine and Its Related Compounds with Chromium Ion and Hemoglobin-bound Chromium
- Studies on the Sulfur-containing Chelating Agents. XXVI. Formation of Mixed Ligand Chelates Containing Penicillamine and Sulfhydryl Compounds
- Studies on Imidazole Derivatives as Chelating Agents. III. Syntheses of Schiff Bases and 4 (5)-Aminomethyl Derivatives and Their Reactions with Metal Ions.
- Studies on Imidazole Derivatives as Chelating Agents. II. Spectrophotometric and Potentiometric Investigations of Acid-base Equilibria of Azoimidazoles
- Studies on Imidazole Derivatives as Chelating Agents. I. Syntheses of Azoimidazoles and Their Reactions with Metal Ions
- Imidazolylazo Compounds as Metallochromic Indicators
- Studies on the Sulfur-containing Chelating Agents. XXIV. Acid Dissociation and Chelate Formation of Penicillamine
- Studies on the Sulfur-containing Chelating Agents. XXV. Chelate Formation of Penicillamine and Its Related Compounds with Copper (II)
- Reduction of Selenocystamine by Thiols
- Studies on the Sulfur-containing Chelating Agents. XXXI. Catalytic Effect of Copper (II) Ion to Formation of Mixed Disulfide
- Syntheses of Metal Complexes of Selenocysteamine
- Syntheses of Related Compounds of Selenocysteamine and Their Complex Formation with Metal Ions
- Studies on the Sulfur-containing Chelating Agents. XXIX. Reaction of Cysteamine and Its Related Compounds with Copper
- Metal Complexes of Selenocysteamine
- Acid Dissociation of Selenocysteamine (2-Aminoethaneselenol)
- Studies on the Sulfur-containing Chelating Agents. XXXVI. Reaction of Palladium Monothioacetylacetonate with Sulfide Ion and Its Application for Determination of Sulfide Ion
- Studies on the Sulfur-containing Chelating Agents. XXXII. The Reaction of Palladium (II) Ion with Monothio-β-diketones and Their Disulfides
- Studies on the Sulfur-containing Chelating Agents. XXIII. Some Investigations on the Quasiaromaticity of Cobalt (III) Thio-β-diketonates by the Spectroscopic Methods
- Studies on the Sulfur-containing Chelating Agents. XXII. Some Metal Chelates of Thio-β-diketones and Bromination of Cobalt (III) Thio-β-diketonates
- The Metal Chelates of Thio Derivatives of β-Diketones
- Syntheses and Chelating Properties of Azothiopyrine Sulfonates
- Studies on the Sulfur-containing Chelating Agents. XIV. Syntheses of β-Mercaptocinnamamides and their Structures.
- Studies on the Sulfur-containing Chelating Agents. XXXIV. Determination of Stability Constant of Mercury Complex of Monothiodibenzoylmethane and Monothiothenoyltrifluoroacetone by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents. XXXV. Determination of Acid Dissociation Constants of N-Phenyl- and N-Ethyl-β-mercaptocin-namamide and Thiodibenzoylmethane by Solvent Extraction Method
- Studies on the Sulfur-containing Chelating Agents.XV.Thioxo-thioenol Tautomerism in Ethyl β-Mercaptothiocinnamates and β-Mercaptocinnamamides
- Studies on the Sulfurcontaining Chelating Agents. XIII. Syntheses of Esters of β-Mercaptothiocinnamic Acid and their Structures.
- Studies on the Sulfurcontaining Chelating Agents. XII. Relationship between Chelating Ability and Chemical Structure of Ligand. (2).
- Studies on the Sulfurcontaining Chelating Agents. XI. Relationship between Chelating Ability and Chemical Structure of Ligand. (1).
- Studies on Sulfur-containing Chelating Agents. X. Mercapto-acid Amides and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. IX. Syntheses of Alkyl or Aryl o-Mercaptophenyl Ketones, Esters of o-Mercaptobenzoic Acid, S-Esters of o-Mercaptothiobenzoic Acid, and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. VIII. Syntheses of α, β-Unsaturated β-Mercapto-acid Esters and their Metal Chelates.
- Studies on Sulfur-containing Chelating Agents. VII. Syntheses of β-Mercaptothiolic Acid Esters and their Metal Chelates.
- Studies on the Sulfur-containing Chelating Agents. VI. Syntheses of β-Mercapto-acid Esters and their Copper and Nickel Chelates.
- Studies on the Sulfur-containing Chelating Agents. V. : Syntheses of β-Mercapto-acid Esters, and their Copper and Nickel Chelates. (1).
- Studies on the Sulfur-containing Chelating Agents. IV. : Structure of Copper Chelate of β-Mercaptoketones.
- Studies on the Sulfur-containing Chelating Agents. III. : Syntheses of β-Mercaptoketones and their Copper Chelates. (3)
- Studies on the Sulfur-containing Chelating Agents. II. Syntheses of β-Mercaptoketones and their Copper Chelates. (2).
- Studies on the sulfur-containing Chelating Agents. I.. Syntheses of β-Mercaptoketones and their Copper Chelates. (1)