Proton Magnetic Resonance Study of Indium (III) and Gallium (III) Binding by Adjacent and Separated Disulfhydryl-Containing Peptides
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概要
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In (III) and Ga (III) binding by new ligands, 2,3-dimercaptopropionylglycine (DMPG) and 2-mercaptopropionyl-L-cysteine (MPC), which involve two adjacent and separated sulfhydryl groups, has been investigated with proton nuclear magnetic resonance spectra. The methylene protons of the 2 : 1 DMPG-In (or Ga) complex were observed as two signals at 3.28 and 3.02 (or 3.33 and 2.98) ppm, indicating a fused-chelate ring formation. On the other hand, MPC formed a polymer In species in addition to the 2 : 1 MPC-In (or Ga) complex which has a rigid configuration similar to the 2 : 1 DMPG-In (or Ga) complex. The coupling constants between the methylene and methine protons and the structure for these In and Ga complexes have been discussed.
- 社団法人日本薬学会の論文
- 1977-09-25
著者
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田中 久
Faculty of Pharmaceutical Sciences, Kyoto University
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杉浦 幸雄
Faculty of Pharmaceutical Sciences, Kyoto University
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杉浦 幸雄
京大薬
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杉浦 幸雄
Faculty Of Pharmaceutical Sciences Kyoto University
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小嶋 仲夫
Faculty of Pharmaceutical Sciences, Kyoto University
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