Absorption Kinetics of Carbenicillin Phenyl Sodium and Carbenicillin Indanyl Sodium in Man
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概要
- 論文の詳細を見る
Carbenicillin phenyl sodium (CFPC) and carbenicillin indanyl sodium (CIPC), which are prodrugs of carbenicillin (CBPC), were orally administered to three volunteers at various doses. The absorptions of these prodrugs were compared by means of moment analysis using urinary excretion data. CFPC showed linear absorption kinetics at 0.5,1.0,and 1.5 g doses. On the other hand, the urinary recovery after oral administration of CIPC decreased and the mean absorption time (MAT) increased as the dose was increased from 0.5 to 1.5 g. Computer simulations by the Runge-Kutta method confirmed the occurrence of capacity-limited absorption of CIPC.
- 社団法人日本薬学会の論文
- 1982-06-25
著者
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谷川原 祐介
第一薬品工業
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谷川原 祐介
Faculty Of Pharmaceutical Sciences Kyoto University
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宇野 豊三
Faculty of Pharmaceutical Sciences, Kyoto University
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山岡 清
Faculty of Pharmaceutical Sciences, Kyoto University
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中川 照真
Faculty of Pharmaceutical Sciences, Kyoto University
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宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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中川 照眞
京都大学 薬研究
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山岡 清
京都大学薬学部
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山岡 清
Faculty Of Pharmaceutical Sciences Kyoto University
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中川 照真
京都大学薬学部
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中川 照眞
京都大学薬学部
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中川 照眞
京大 大学院薬学研究科
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宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
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宇野 豊三
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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