Reaction Products of Sulbactam with Pyrazole, 1,2,4-Triazole and Imidazole : High-Performance Liquid Chromatographic Behavior and Structural Investigation
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概要
- 論文の詳細を見る
The reactions of sulbactam (I) with pyrazole, 1,2,4-triazole and imidazole in weakly alkaline solutions yielded 1-(5-carboxy-6-methyl-6-sulfino-4-aza-2-heptenoyl)-pyrazole (III), -1,2,4-triazole (IV), and -imidazole (V), respectively. The proton nuclear magnetic resonance spectra and high-performance liquid chromatographic (HPLC) behavior indicate that III, IV and V each exist as a mixture of E- and Z-isomers in a ratio of about 2 : 1 in aqueous solutions at low temperature, and that rapid interconversion between the E- and Z-isomers occurs at high temperature. Compounds III, IV and V were converted to methyl 5-carboxy-6-methyl-6-sulfino-4-aza-2-heptenoate (II) in methanol.
- 社団法人日本薬学会の論文
- 1985-11-25
著者
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萩中 淳
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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宇野 豊三
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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中川 照眞
Faculty Of Pharmaceutical Sciences Kyoto University
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若居 純子
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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安田 博幸
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
-
萩中 淳
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
-
安田 博幸
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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宇野 豊三
Faculty Of Pharmaceutical Sciences Kyoto University
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若居 純子
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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宇野 豊三
Faculty of Pharmaceutical Sciences, Mukogawa Women's University
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