Evaluation of Hydrophobic Interaction between Acidic Drugs and Bovine Serum Albumin by Reversed-Phase High-Performance Liquid Chromatography
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概要
- 論文の詳細を見る
The contribution of hydrophobic interaction to the protein binding of acidic drugs has been evaluated in terms of a new hydrophobic index (r-value), defined as the slope of the log-log plots of capacity factor vs. reciprocal of methanol concentration in an aqueous binary mobile phase, measured by the reversed-phase high-performance liquid chromatography. The logarithms of the binding constants (log K_1) of the selected acidic drugs and the related aromatic carboxylic acids indicated linear relationship with their r-values, suggesting that the effect of hydrophobicity on protein binding can be explained similarly to that on the retention onto the reversed-phase stationary ligand.
- 社団法人日本薬学会の論文
- 1991-03-25
著者
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中川 照眞
Faculty Of Pharmaceutical Sciences Kyoto University
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貝原 徳紀
Faculty of Pharmaceutical Sciences, Kyoto University
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廣瀬 美砂子
Faculty of Pharmaceutical Sciences, Kyoto University
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貝原 徳紀
Faculty Of Pharmaceutical Sciences Kyoto University
-
廣瀬 美砂子
Faculty Of Pharmaceutical Sciences Kyoto University
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