Improved Flow Injection Analysis (FIA) Method for Determining Selenium in Biological Samples, and the Effect of Captopril Administration on Selenium Levels and Glutathione Peroxidase Activity in Rat
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概要
- 論文の詳細を見る
An improved flow injection analysis (FIA) method has been developed for the determination of trace selenium in biological samples, and this method has been applied to investigate the effect of captopril, an antihypertensive drug having a thiol group, on selenium concentrations in the rat blood, liver and urine. After oral administration of captopril, selenium levels in the blood decreased, while those in the liver increased significantly. However, no pronounced effect was observed on the urinary excretion rate. The glutathione peroxidase activities in the blood and the liver were comparable to the changes in the selenium levels.
- 社団法人日本薬学会の論文
- 1993-11-15
著者
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田中 久
Kyoto Pharmaceutical University
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安井 裕之
Faculty Of Pharmaceutical Sciences Kyoto University
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中川 照眞
Faculty Of Pharmaceutical Sciences Kyoto University
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中川 照眞
京都大学 薬研究
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中川 照真
京都大学薬学部
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中川 照眞
京都大学薬学部
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中川 照眞
京大 大学院薬学研究科
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鈴木 信幸
Faculty of Pharmaceutical Sciences, Kyoto University
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藤田 選子
Faculty of Pharmaceutical Sciences, Kyoto University
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青山 英嗣
Faculty of Pharmaceutical Sciences, Kyoto University
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青山 英嗣
Faculty Of Pharmaceutical Sciences Kyoto University
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Yasui H
Kyoto Univ. Kyoto Jpn
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藤田 選子
Faculty Of Pharmaceutical Sciences Kyoto University
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鈴木 信幸
Faculty Of Pharmaceutical Sciences Kyoto University
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