Epimerization of Amoxicillin Piperazine-2,5-dione in Acidic Solutions
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概要
- 論文の詳細を見る
Products formed from amoxicillin by reaction with glucose in solution (pH 9.2) were isolated and examined by high-performance liquid chromatography, nuclear magnetic resonance, ultraviolet and mass spectroscopy, and optical rotation measurement. The products were elucidated to be the corresponding (2R)-piperazine-2', 5'-dione and the (2S)-epimer. The (2R)-piperazine-2', 5'-dione readily epimerized to the (2S)-epimer in acidic solutions, and at equili8brium, the (2R)- and (2S)-epimers existed in a ration of 2 : 1. The epimerization also took place in alkaline solutions to a small extent. The 2-position in these compounds corresponds to the 5-position in the starting amoxicillin.
- 公益社団法人日本薬学会の論文
- 1986-05-25
著者
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萩中 淳
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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若居 純子
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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