Hydroxylation of Acetanilide by Iron-Sulfur and Nickel-Sulfur Complex Systems
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概要
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The hydroxylation of acetanilide by iron-sulfur complexes produces p- and o-acetaminophenols as main products. The yield of p-acetaminophenol is 34.8 and 31.4% in the catalytic systems of dithiothreitol (DTT)-iron-inorganic sulfur (S) and glutathione (GSH)-Fe-S complexes, respectively. The turnover number of the acetanilide-hydroxylation is 3.9×10^<-2> and 3.5×10^<-2> (mol p-acetaminophenol/min/mol complex) in the DTT-Fe-S and GSH-Fe-S complex systems, respectively. The DTT-nickel complex incorporates inorganic sulfur to form unstable DTT-Ni-S complex. The DTT-Ni complexes have also high catalytic effect on the hydroxylation of acetanilide.
- 社団法人日本薬学会の論文
- 1978-01-25
著者
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田中 久
Faculty of Pharmaceutical Sciences, Kyoto University
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杉浦 幸雄
Faculty of Pharmaceutical Sciences, Kyoto University
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杉浦 幸雄
京大薬
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杉浦 幸雄
Faculty Of Pharmaceutical Sciences Kyoto University
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國嶋 資子
Faculty of Pharmaceutical Sciences, Kyoto University
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國嶋 資子
Faculty Of Pharmaceutical Sciences Kyoto University
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