Synthesis of [^<125>I]Iodoclorgyline, a Selective Monoamine Oxidase A Inhibitor, and Its Biodistribution in Mice

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概要

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• A new radioiodinated monoamine oxidase A (MAO-A) specific inhibitor, [^<125>I]iodoclorgyline, was synthesized from its tin precursor by iododestannylation reaction using sodium [^<125>I]iodide and hydrogen peroxide with high yield and site specificity. The product possessed a high radiochemical purity as well as high specific activity. The method can be readily applicable for labeling with ^<123>I, a very suitable radioisotope for in vivo imaging with single photon emission computer tomography (SPECT). Biodistribution studies of the [^<125>I]iodoclorgyline in mice showed high initial uptake in the brain, and brain radioactivity reached a constant level at 60 min after intravenous injection. The results suggested that [^<125>I]iodoclorgyline might have potential as a radiopharmaceutical for MAO-A studies in the brain with SPECT.

• 社団法人日本薬学会の論文
• 1991-12-25

著者

• 横山 陽

  Faculty of Pharmaceutical Sciences, Kyoto University

• 間賀田 泰寛

  京都大学医学部

• 大桃 善朗

  Osaka University of Pharmaceutical Sciences

• 村上 勝彦

  Osaka University of Pharmaceutical Sciences

• 平田 雅彦

  Faculty of Pharmaceutical Sciences Kyoto University

• 田中 千秋

  Osaka University of Pharmaceutical Sciences

• 平田 雅彦

  Osaka University of Pharmaceutical Sciences

• 間賀田 泰寛

  Kyoto University Hospital

• 間賀田 泰寛

  京都大学医学部放射線核医学講座

• 横山 陽

  京大

• 田中 千秋

  Osaka College Of Pharmacy

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