Redioiodinated Phenoxyacetic Acid Derivatives as Potential Brain Imaging Agents. I. : Effcient Synthesis via Trimethylsilyl Intermediates

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概要

• 論文の詳細を見る

• The usefulness of radioiodination via demetallation of aryltrimethylsilanes was demonstrated. The radioiodination reaction was found to be very rapid and the regiospecific incorporation of radioiodine could be carried out with high radiochemical yields and high radiospecific activity. ^<125>I-Labeled dimethylaminoethyl iodophenoxyacetate derivatives (5a-e), dimethylaminoethyl iodophenoxyacetamide derivatives (7a-c), iodophenoxyethyl ethylenediamine derivatives (9,14) and an iodophenoxyethylpiperazine derivative (18) were efficiently synthesized from the corresponding aryltrimethylsilyl intermediates (4a-e, 6a-c, 8,13,17) by this method.

• 社団法人日本薬学会の論文
• 1989-09-25

著者

• 横山 陽

  Faculty of Pharmaceutical Sciences, Kyoto University

• 間賀田 泰寛

  京都大学医学部

• 大桃 善朗

  Osaka University of Pharmaceutical Sciences

• 田中 千秋

  Osaka University of Pharmaceutical Sciences

• 間賀田 泰寛

  Faculty of Medicine, Kyoto University

• 奥山 慎一郎

  Osaka University of Pharmaceutical Sciences

• 植野 容子

  Osaka University of Pharmaceutical Sciences

• 間賀田 泰寛

  京都大学医学部放射線核医学講座

• 田中 千秋

  Osaka College Of Pharmacy

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