Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the N^<im>-Function of Histidine
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概要
- 論文の詳細を見る
The chemical behavior of N^<im>-p-methoxybenzenesulfonylhistidine, His (MBS), was examined. This new N^<im>-protecting group was removable by HF or N-hydroxybenzotriazole, like the N^<im>-Tos group, but was more acid-stable than the Tos group with methanesulfonic acid or HBr. The N^<im>-MBS group was stable to treatment with trifluoroacetic acid in the presence of anisole, but was found to be cleaved smoothly by the same acid in the presence of dimethylsulfide at room temperature within an hour. The N^<im>-Tos group was also removable under similar conditions, but at a somewhat lower rate.
- 公益社団法人日本薬学会の論文
- 1980-03-25
著者
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北川 幸己
徳島大学薬学部
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矢島 治明
Faculty of Pharmaceutical Sciences, Kyoto University
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秋田 正
Faculty of Pharmaceutical Sciences, Tokushima University
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木曽 良明
Department of Medicinal Chemistry, Kyoto Pharmaceutical University
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木曽 良明
Department Of Medicinal Chemistry Kyoto Pharmaceutical University
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秋田 正
Faculty Of Pharmaceutical Sciences The University Of Tokushima
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北川 幸己
Faculty Of Pharmaceutical Sciences University Of Tokushima
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矢島 治明
Faculty Of Pharmaceutical Sciences Kyoto University
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