Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P

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概要

• 論文の詳細を見る

• The undecapeptide amide, H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH_2,corresponding to the entire amino acid sequence of substance P, a bovine hypothalamic peptide, was synthesized by the conventional method. This and C-terminal tetra, penta, hexa, hepta and octapeptide amides were submitted for biological assays. Synthetic substance P caused considerable decrease in blood pressure and heart rate in anesthetized rat, but other shorter chain peptides were less active. When contractility on isolated guinea-pig ileum was examined, the heptapeptide amide exhibited much higher activity than synthetic substance P.

• 公益社団法人日本薬学会の論文
• 1973-11-25

著者

• 北川 幸己

  徳島大学薬学部

• 北川 幸己

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 瀬川 富郎

  Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University

• 瀬川 富郎

  Pharmaceutical Institute, School of Medicine, Hiroshima University

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