Synthesis of the Hexadecapeptide corresponding to Positions 1 through 16 of Porcine Motilin, a Gastric Motor Activity Stimulating Polypeptide

スポンサーリンク

概要

• 論文の詳細を見る

• The hexadecapeptide corresponding to positions 1 to 16 of porcine motilin was synthesized in a conventional manner. The synthetic peptide exhibited the activity of 3% of that of the synthetic motilin, when tested using rabbit duodenal muscle in vitro.

• 公益社団法人日本薬学会の論文
• 1977-08-25

著者

• 北川 幸己

  徳島大学薬学部

• 矢島 治明

  Faculty of Pharmaceutical Sciences, Kyoto University

• 瀬川 富郎

  Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University

• 秋田 正

  Faculty of Pharmaceutical Sciences, Tokushima University

• 秋田 正

  Faculty Of Pharmaceutical Sciences The University Of Tokushima

• 北川 幸己

  Faculty Of Pharmaceutical Sciences University Of Tokushima

• 甲斐 啓幸

  Research laboratories, Sumitomo Pharmaceuticals Co., Ltd.,

• 矢島 治明

  Faculty Of Pharmaceutical Sciences Kyoto University

• 甲斐 啓幸

  Research Laboratories Sumitomo Pharmaceuticals Co. Ltd.

• 瀬川 富郎

  Faculty Of Pharmaceutical Sciences School Of Medicine Hiroshima University

関連論文

• 抗アレルギー薬の研究(第1報)1,2,3-三置換-2-propen-1-one類, 3,4-二置換-4-oxo-2-butenoic Acid類及び関連化合物について
• Studies on Peptides. Application of Trifluoromethanesulphonic Acid as a Deblocking Reagent to the Synthesis of Neurotensin
• Studies on Peptides. LXIV. Synthesis of the Tritetracontapeptide corresponding to the Entire Amino Acid Sequence of Porcine Gastric Inhibitory Polypeptide (GIP)
• Synthesis of Amaryllidaceae Alkaloids, (±)-Cherylline and (±)-Latifine
• Solution Synthesis of Human Neuropeptide Y (hNPY)
• 2-Propen-1-one 誘導体の合成と抗真菌活性^
• Studies on Peptides. CXXXVI. : Solution-Phase Synthesis of a 37-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Calcitonin Gene-Related Peptide (hCGRP)
• Studies on Peptides. XCIV. Synthesis and Activity of Kyotorphin and Its Analogs
• Studies on Peptides. LXXIX. : By-Products derived from N^α-Protected Tryptophan by Acids
• Studies on Peptides. LXXVIII. Synthesis of the Nonacosapeptide corresponding to the Entire Amino Acid Sequence of Avian Glucagon (Duck)
• Studies on Peptides. LXXVII. Synthesis of the Protected Heptadecapeptide corresponding to Positions 13-29 of Avian Glucagon (Duck)
• Studies on Peptides. LXXIII. Examination of the Methanesulphonic Acid Procedure for the Synthesis of Peptides containing Methionine
• Studies on Peptides. LXX. Synthesis of Two Octadecapeptides corresponding to the Entire Amino Acid Sequence of Camel β-Melanocyte-stimulating Hormones
• Studies on Peptides. LXIX. Selective Removal of Acid Labile α-Amino Protecting Groups with Dilute Sulfonic Acids
• Studies on Peptides. LXIII. Synthesis of the Octacosapeptide Corresponding to Positions 1 through 28 of Porcine Gastric Inhibiting Polypeptide (GIP)
• Studies on Peptides. LXII. Synthesis of the Protected Octadecapeptide corresponding to Positions 26 through 43 of Porcine Gastric Inhibitory Polypeptide (GIP)
• Studies on Peptides. XLIX. Synthesis of the Octadecapeptide corresponding to the Entire Amino Acid Sequence of Porcine β-Melanocyte-stimulating Hormone
• Tyr-Arg(キョートルフィン)ユニットを持つ新鎮痛性ペンタペプチド、ネオキョートルフィンの牛脳よりの単離(発表論文抄録(1983年))
• Synthesis and Activity of a newly Isolated Analgesic Pentapeptide, Neo-kyotorphin
• Studies on Peptides. CXLI. : Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Porcine GIP (Glucose-Dependent Insulinotropic Polypeptide)
• Studies on Peptides. CXXXIX. : Solution Synthesis of a 42-Residue Peptide Corresponding to the Entire Amino Acid Sequence of Human Glucose-Dependent Insulinotropic Polypeptide (GIP)
• Studies on Peptides. CXXXIII. : Synthesis and Biological Activity of Galanin, a Novel Porcine Intestinal Polypeptide
• Studies on Peptides. CXXXI. Synthesis of Adrenorphin and Enkephalin Analogs
• SYNTHESIS OF A 42 RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GIP
• Studies on Peptides. CL. Syntheses of [D-His^2]-Analogs of Enkephalin and Adrenorphin and Several [D-Arg^2]enkephalin Analogs(Organic,Chemical)
• Synthesis and Analgesic Activity of Neo-kyotorphin Analogs
• ウシ脳からの麻酔作用を持つ新たなペンタペプチド, Neo-Kyotorphinの単離
• Studies on Peptides. CXXXIV. : Evaluation of S-1-Adamantylcysteine for Peptide Synthesis
• Studies on Peptides. LXXX. N^G-Mesitylene-2-sulfonylarginine
• Studies on Peptides. LX. Synthesis of the Nonatriacontapeptide corresponding to the Entire Amino Acid Sequence of Bovine Adrenocorticotropic Hormone
• Studies on Peptides. XCVII. Synthesis of Porcine Glu^8-Vasoactive Intestinal Polypeptide (VIP)
• Studies on Peptides. XLI. Synthesis of the Protected Hexadecapeptide Corresponding to Positions 13 to 28 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides. XXIV. Some Observation on the Urethan Formation during the Mixed Anhydride Procedure in Peptide Synthesis
• Studies on Peptides. XXIII. Total Synthesis of Monkey β-Melanocyte-stimulating Hormone
• Studies on Peptides. XXII. Synthesis of the partially Protected Pentadecapeptide related to Monkey and Human β-Melanocyte-stimulating Hormones
• Studies on Peptides. XVI. Regeneration of Lysine from N^ε-Formyllysine by Aqueous Hydrazine or Hydroxylamine and Their Application to the Synthesis of α-Melanocyte-stimulating Hormone
• Studies on Peptides. XV. Synthesis of Prolyltyrosylarginylmethionine, the Tetrapeptide situated within the Amino Acid Sequences of Monkey and Human β-Melanocyte-stimulating Hormones.
• Studies on Peptides. XIV. Synthesis of Lysyl-S-benzylcysteinylalanylglutaminyl-S-benzyl-cysteinylhistidine, a Peptide related to Horse Heart Cytochrome C.
• Studies on Peptides. XII.Synthesis of the Decapeptide corresponding to the C-Terminal Portion of β-Melanocyte-stimulating Hormone
• Studies on Peptides. VI. Synthesis of Three Stereoisomeric Pentapeptides of Histidylphenyl-alanylarginyltryptophylglycine Possessing D-Phenylalanyl-D-arginyl Moiety within the Sequence and Their Melanocyte-stimulating Activities in vitro
• Enzyme Immunoassay of Somatostatin (SS)-like Immunoreactive Substance in Bovine Milk
• Studies on Peptides. CLVI. Synthesis of Second Human Calcitonin Gene-Related Peptide (β-hCGRP) by Application of a New Disulfide-Bonding Reaction with Thallium(III) Trifluoroacetate(Organic,Chemical)
• Studies on Peptides. CXLII. : Synthesis of Des-1-Ala-des-α-amino-Human Calcitonin Gene-Related Peptide
• Synthesis of [27-Tyr]-Cholecystokinin-Pancreozymin (CCK-PZ)
• Studies on Peptides. LVII. Synthesis of the Octadecapeptide corresponding to the Entire Amino Acid Sequence of Equine β-Melanocyte-stimulating Hormone
• Studies on Peptides. LIII. Synthesis of the Docosapeptide Corresponding to the Entire Amino Acid Sequence of Porcine ACTH-Like Intermediate Lobe Peptide (CLIP)
• Studies on Peptides. XLIV. Synthesis of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop) by the Fragment Condensation Procedure on Polymer Support
• Studies on Peptides. XLIII. Synthesis of Two Protected Peptides Related to the C-Terminal Portion of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides. XLII. Synthesis of the Protected Nonapeptide Corresponding to Positions 29 to 37 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides. XL. Synthesis of the Protected Dodecapeptide corresponding to Positions 1 to 12 of the Basic Trypsin Inhibitor from Bovine Pancreas (Kunitz and Northrop)
• Studies on Peptides, XXXIX. N-Isobutoxycarbonyl-2-alkoxy-1,2-dihydroquinoline Derivatives, as Coupling Reagents in Peptide Synthesis
• Studies on Peptides. XXXV. Some p-Methoxybenzyloxycarbonyl-Amino Acid Derivatives
• Studies on Peptides. XXXI. Synthesis of Two Model Pentapeptides related to Clostridial Ferredoxin
• Studies on Peptides. XXX. Trichloroethyloxycarbonylhydrazine
• Studies on Peptides. XXIX. p-Methoxybenzyl Mixed Carbonates
• Studies on Peptides. Warning for the Explosive Carbazide Formation during the Direct Preparation of t-Butyl Azidoformate or p-Methoxybenzyl Azidoformate
• Studies on Peptides. XXV. A Convenient Procedure for the Preparation of p-Methoxybenzyl Azidoformate
• Studies on Peptides. CXLVI. : Synthesis of Gln^-Motilin and Examination of Its Immunological Properites
• Studies on Peptides. CXLV. : Synthesis of a 27-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Canine Gastrin-Releasing Polypeptide (cGRP)
• Studies on Peptides. CXL. : Synthesis of Human Gastrin-Releasing Polypeptide (hGRP)
• Studies on Peptides. CXXX. Convenient Procedure for the Reduction of Methionine Sulfoxide
• SYNTHESIS OF A 27-RESIDUE PEPTIDE CORRESPONDING TO THE ENTIRE AMINO ACID SEQUENCE OF HUMAN GASTRIN-RELEASING PEPTIDE (hGRP)
• Studies on Peptides. CV. Synthesis of Chicken Neurotensin
• Synthesis and Biological Activity of 8-L-Ala-Motilin and 8-D-Ala-Motilin
• Studies on Peptides. CLI. Syntheses of Cystine-Peptides by Oxidation of S-Protected Cysteine-Peptides with Thallium(III) Trifluoroacetate(Organic,Chemical)
• Studies on Peptides. CXLIII. : Evaluation of β-Methylaspartate for Peptide Synthesis
• Studies on Peptides. CI. Synthesis of a Wasp Venom, Mastoparan M
• Synthesis of Granuliberin-R and Various Fragment Peptides and Their Histamine-Releasing Activities
• Synthesis of the Dodecapeptide Amide corresponding to the Entire Amino Acid Sequence of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Synthesis of Granuliberin-R, a New Frog Skin Peptide from Rana rugosa
• Circular Dichroism of Active Fragments of α-Melanocyte-stimulating Hormone
• Studies on Peptides. CX. Solution Synthesis of the Tetratriacontapeptide Amide corresponding to Positions 1 to 34 of Human Parathyroid Hormone
• Studies on Peptides. CIX. Synthesis of the Octatriacontapeptide Corresponding to Positions 1 to 38 of Human Parathyroid Hormone
• Synthesis of the Nonacosapeptide corresponding to Mammalian Glucagon
• Synthesis of Porcine Motilin and Its D-Phe^1-Analog by the Use of Methanesulfonic Acid
• Synthesis of a Heptacosapeptide Amide corresponding to the Entire Amino Acid Sequence of Chicken Gastrin Releasing Peptide (GRP)
• Synthesis of a Heptacosapeptide Amide corresponding to the Entire Amino Acid Sequence of Gastric Gastrin Releasing Peptide
• A Deblocking Method using Thioether-Sulfonic Acid Systems. Application to the Synthesis of Met-Enkephalin
• Selective Transport of the Salts of Amino Acid Esters through an Organic Liquid Membrane with Antamanide as a Carrier
• Studies on Peptides. CXLVIII. : Application of a New Deprotecting Procedure with Trimethylsilyl Trifluoromethanesulfonate for the Syntheses of Two Porcine Spinal Cord Peptides, Neuromedin U-8 and Neuromedin U-25(Amaryllidaceae)(Organic,Chemical)
• Studies on Peptides. CLXVI. : Solid-Phase Syntheses and Immunological Properties of Fragment Peptides Related to Human Hepatitis B Virus Surface Antigen (HBsAg) and Its Pre-S2 Gene
• Studies on Peptides. CLVII. : Synthesis of a Frog-Skin Peptide, Sauvagine
• Studies on Peptides. CXXXII. : Evaluation of Two β-Carboxyl Protecting Groups of Aspartic Acid, Cycloheptyl and Cyclooctyl, for Peptide Synthesis
• Studies on Peptides. CXXXV. : Preparation of Seven Peptide Fragments for the Synthesis of Human Calcitonin Gene-Related Peptide (hCGRP)
• Synthesis of Canine Motilin, a Gastric Motor Activity-Stimulating Polypeptide, and Its N^1-Substituted Analogs
• Enzyme Immunoassay of a Substance P-like Immunoreactive Substance in Human Plasma and Saliva
• Synthesis of the Hexadecapeptide corresponding to Positions 1 through 16 of Porcine Motilin, a Gastric Motor Activity Stimulating Polypeptide
• Alternative Synthesis of Porcine Secretin and Apparent Autolysis of the Product
• SYNTHESIS OF A NEWLY ISOLATED OPIOID TRIDECAPEPTIDE, RIMORPHIN, FROM PITUITARY USING A TRIFLUOROACETIC ACID-THIOANISOLE DEPROTECTION SYSTEM
• Studies on Peptides. LXXXV. A New Deprotecting Procedure for p-Toluenesulfonyl and p-Methoxybenzenesulfonyl Groups from the N^-Function of Histidine
• Synthesis and Activity of C-Terminal Heptapeptides of Tachykinins and Bombesin-like Peptides
• Synthesis of Two Substance P Analogs, [8-Tyr] and [5-Asn] Substance P
• Suppressing Effect of Thioanisole on a Side Reaction during the Acidolytic Cleavage of Protecting Groups of Tyrosine
• Alternative Synthesis of Substance P
• Studies on Peptides. LVIII. Synthesis of Tyr^1-Substance P
• ラクトアミドおよびマンデルアミドとアミノ酸およびアミンとの融解反応
• Studies on Peptides. XXXVII. Suppressed Racemization in Peptide Synthesis by the Use of p-Chloro or p-Nitrobenzene-sulfohydroxamic Acid
• Studies on Peptides. XXXVIII. Structure-Activity Correlations in Substance P
• Studies on Peptides. XXXIV. Conventional Synthesis of the Undecapeptide Amide corresponding to the Entire Amino Acid Sequence of Bovine Substance P
• “Safety-catch”型保護基の特性を活用した硫酸化チロシン含有ペプチドの新規合成法の開発

もっと見る 閉じる

スポンサーリンク