Rectal Absorption of Gly^1-α^<1-18> Adrenocorticotropin Amide
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概要
- 論文の詳細を見る
Plasma corticosteroids level was determined after rectal administration of Gly^1-α^<1-18> ACTH amide to hypophysectomized rat. When the aqueous solution of the peptide was administered, the corticosteroidogenic response was detected in 5 min and reached its maximum in 15 to 30 min after the administration. The half maximum effective dose from dose response curve was estimated to be 40 μg/kg. The extent of absorption of the peptide was markedly influenced by suppository bases as well as the nonionic surfactants added to the bases. Polyoxyethylene (20) cetyl ether (BC-20TX) enhanced the absorption from both hydrophobic and hydrophilic bases while BC-7 stimulated that from only hydrophobic bases.
- 公益社団法人日本薬学会の論文
- 1978-04-25
著者
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田中 明
Shionogi Research Laboratory, Shionogi Co., Ltd.
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二口 眞也
Shionogi Research Laboratory Shionogi And Co. Ltd.
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田中 明
Shionogi Research Laboratory Shionogi And Co. Ltd.
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平田 雅春
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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田村 孝子
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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小田口 州宏
Shionogi Research Laboratory, Shionogi and Co., Ltd.
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小田口 州宏
Shionogi Research Laboratory Shionogi And Co. Ltd.
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田村 孝子
Shionogi Research Laboratory Shionogi And Co. Ltd.
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平田 雅春
Shionogi Research Laboratories Shionogi & Co. Ltd.
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平田 雅春
Shionogi Research Laboratory Shionogi And Co. Ltd.
関連論文
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