活性エステルとして4-Morpholinyl Esterのペプチド合成への応用(第2報)
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概要
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Following the previous work, several new N-carbobenzoxyamino acid 4-morpholinyl esters (Arg (NO_2), Asp (β-OMe), Glu (γ-OMe), Ile, Leu, Met, Thr, and Trp) were prepared. Their coupling with Gly-OEt gave the corresponding N-carboenzoxydipeptide esters. Reactions of these 4-morpholinyl esters with amino acid sodium salts in aqueous organic solvent gave the corresponding N-carbobenzoxydipeptides, while good results were not obtained in the condensations which involved sterically hindered amino acids. Young's racemization test gave a high optical purity of 98%. Further, several reactions of N-benzoylglycine 4-morpholinyl ester were examined, and it was found that the ester was comparatively stable to acetic acid or 25% HBr in acetic acid, giving about 70% recovery in both media.
- 公益社団法人日本薬学会の論文
- 1973-11-25
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- タフトシン関連ペプチドの合成(第2報)
- タフトシン関連ペプチドの合成(第1報)
- 活性エステルとして4-Morpholinyl Esterのペプチド合成への応用(第4報)
- 活性エステルとして4-Morpholinyl Esterのペプチド合成への応用(第3報)
- 活性エステルとして4-Morpholinyl Esterのペプチド合成への応用(第2報)
- 活性エステルとして4-Morpholyl Esterのペプチド合成への応用