Ischemia-Induced Changes in Brain Levels of Monoamines and Their Metabolites of Mice and Rats : Some Protective Effects of Naftidrofuryl
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概要
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Employing two types of brain ischemic animal models, an attempt was made to evaluate the protective effect of naftidrofuryl as the normalizing effect on the ischemia-induced changes in the brain levels of monoamines and metabolites. 1) During 2 min ligation of both left and right common carotid arteries of mice, dopamine (DA) content alone significantly decreased among three monoamines and four metabolites measured by a high performance liquid chromatography-electrochemical detection method. Pretreatment with naftidrofuryl oxalate (45 mg/kg, i.p.) was found to prevent the DA change, but the lower dose (15 mg/kg, i.p.) of the drug or any other drug tested individually (vinpocetine hydrochloride : 2 mg/kg, Ca hopantenate : 0.1 g/kg, citicoline : 0.1 g/kg, i.p.) had no such effect. 2) Infusion of carbon microsphere (500 particles/100 μl of 20% dextran/1.5 min/rat) into the right internal carotid artery induced various degree of time-dependent changes in the behavior and also in the brain levels of monoamines and metabolites. Embolized rats which otherwise would survive for at least 6 d after infusion, were divided into the lightly-infarcted and severely-infarcted groups by grading the behavioral abnormality. Subsequent treatments with naftidrofuryl oxalate (15 mg/kg, i.p., twice daily, totally 4 times) which was begun 16 h after microsphere injection, was found to accelerate the recovery rate of brain dopamine level once decreased by the embolism though only in the lightly-infarcted group. The significance of the results obtained herein were discussed in relation to the clinical effectiveness of naftidrofuryl in human brain ischemic diseases.
- 公益社団法人日本薬学会の論文
著者
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NAKAMUTA HIROMICHI
Department of Parmacology, Setsunan University
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KOIDA MASAO
Department of Parmacology, Setsunan University
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Koida Masao
Department Of Pharmacology Faculty Of Pharmaceutical Sciences:research Institute Of Drug Safety Sets
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Koida Masao
Department Of Parmacology Setsunan University
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MUGURUMA Keiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences
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HIRAMATSU Yasuzo
Department of Pharmacology, Faculty of Pharmaceutical Sciences
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OGAWA Yasunao
Department of Pharmacology, Faculty of Pharmaceutical Sciences
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Ogawa Yasunao
Department Of Pharmacology Faculty Of Pharmaceutical Sciences:research Institute Of Drug Safety Sets
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Muguruma Keiko
Department Of Pharmacology Faculty Of Pharmaceutical Sciences:research Institute Of Drug Safety Sets
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Nakamuta Hiromichi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences:research Institute Of Drug Safety Sets
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Nakamuta Hiromichi
Department Of Parmacology Setsunan University
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Hiramatsu Yasuzo
Department Of Pharmacology Faculty Of Pharmaceutical Sciences:research Institute Of Drug Safety Sets
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