Studies on Peptides. CLIV. : Synthesis of a 36-Residue Peptide Amide Corresponding to the Entire Amino Acid Sequence of Human Pancreatic Polypeptide(Organic,Chemical)

概要

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A 36-residue peptide corresponding to the entire amino acid sequence of human pancreatic polypeptide (hPP) was synthesized by the solution method. A new Asp derivative, Asp(OMen) [Men=menthyl] was employed. Seven fragments served to construct the peptide backbone of hPP and all the protecting groups employed were cleaved by 2 M trimethylsilyl trifluoromethane-sulfonate-diphenylsulfide/trifluoroacetic acid. The synthetic peptide inhibited protein secretion from rat pancreas.
公益社団法人日本薬学会の論文
1987-09-25