Androgen Induces Production of Male Effect Pheromone in Female Goats

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概要

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• Previously we showed that the primer pheromone responsible for the "male effect" was produced in specific skin regions of castrated male goats by androgen treatments. In the present study, we examined whether androgen can also induce production of the male effect pheromone in female goats. Capsules containing dihydrotestosterone (DHT) or testosterone (T) were subcutaneously implanted into six ovariectomized (OVX) goats for 28 days. Small skin samples were collected from the head and rump regions, and the pheromone activity of their ether extracts was examined using a bioassay that monitors the electrophysiological manifestation of the hypothalamic gonadotropin-releasing hormone pulse generator as multiple-unit activity. Behaviors of OVX goats towards ovary-intact estrous goats were also examined before and at the end of DHT or T treatment. Before androgen treatment, neither the head nor rump skin samples in OVX goats showed pheromone activity. DHT treatment induced pheromone activity in the head skin sample of six OVX goats and in the rump skin sample of two OVX goats. Similar results were obtained by DHT treatment. In addition, OVX goats treated with T showed masculine-type sexual behaviors such as courtship and mounting behaviors towards the estrous goats. These results demonstrate that androgen is capable of inducing primer pheromone activity in the female and suggest that the synthesis pathway of the male effect pheromone exists in both sexes in the goat.

• 2007-08-01

著者

• 岩田 惠理

  東京大学大学院農学生命科学研究科獣医動物行動学研究室

• 岩田 恵理

  東京大学大学院農学生命科学研究科

• OHKURA Satoshi

  Laboratory of neuro-endocrinology, National Institute of Agrobiological Sciences

• MORI Yuji

  Laboratory of Veterinary Ethology, The University of Tokyo

• OKAMURA Hiroaki

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• Ohkura S

  Department Of Bioengineering Sciences Graduate School Of Bioagricultural Sciences Nagoya University

• Ohkura Satoshi

  Laboratory Of Animal Production Science Graduate School Of Bioagricultural Sciences Nagoya Universit

• Ohkura Satoshi

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• KAKUMA Yoshie

  Laboratory of Veterinary Ethology, The University of Tokyo

• ICHIMARU Toru

  Laboratory of Veterinary Ethology, The University of Tokyo

• YONEZAWA Tomohiro

  Laboratory of Veterinary Physiology, The University of Tokyo

• MOMOZAWA Yukihide

  Laboratory of Veterinary Ethology, The University of Tokyo

• HASHIZUME Chie

  Laboratory of Veterinary Ethology, The University of Tokyo

• IWATA Eri

  Laboratory of Veterinary Ethology, The University of Tokyo

• KIKUSUI Takefumi

  Laboratory of Veterinary Ethology, The University of Tokyo

• TAKEUCHI Yukari

  Laboratory of Veterinary Ethology, The University of Tokyo

• Mori Y

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Okamura H

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Ohno Hiroaki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Yonezawa Tomohiro

  Laboratory Of Veterinary Physiology Kitasato University

• Yonezawa Tomohiro

  Laboratory Of Veterinary Physiology The University Of Tokyo

• Ohkura S

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Mori Yuji

  Univ. Tokyo Tokyo Jpn

• Mori Yuji

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Okamura Hiroaki

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Iwata E

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Iwata Eri

  Laboratory Of Veterinary Ethology Department Of Animal Resource Science The University Of Tokyo

• Ichimaru T

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Kakuma Yoshie

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Hashizume Chie

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Iwata Eri

  Laboratory Of Marine Microbiology Division Of Applied Biosciences Graduate School Of Agriculture Kyo

• Takeuchi Yukari

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Momozawa Yukihide

  Laboratory Of Veterinary Ethology University Of Tokyo

• Ichimaru Toru

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Mori Yuji

  Laboratory Of Veterinary Ethology Animal Resource Science The University Of Tokyo

• Okamura Hiroaki

  Laboratory Of Adaptation Physiology National Institute Of Animal Industry Ministry Of Agriculture Fo

• Yonezawa Tomohiro

  Department Of Veterinary Physiology Veterinary Medical Science The University Of Tokyo

• Kamura Yoshie

  Laboratory of Veterinary Ethology, The University of Tokyo

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

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