Central Administration of Neurokinin B Activates Kisspeptin/NKB Neurons in the Arcuate Nucleus and Stimulates Luteinizing Hormone Secretion in Ewes During the Non-Breeding Season

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概要

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• Human genetic studies have suggested that kisspeptin and neurokinin B (NKB) play pivotal roles in the control of gonadotropin-releasing hormone (GnRH) secretion. However, the role of NKB in this context is less clear compared with that of kisspeptin. In the present study, we investigated the ratio of colocalization of kisspeptin and NKB in neurons in the arcuate nucleus (ARC), the effects of intracerebroventricular infusion of NKB on luteinizing hormone (LH) secretion and whether the treatment activates ARC kisspeptin/NKB neurons in seasonally anestrous ewes. Double-labeling immunohistochemistry revealed that the majority of kisspeptin neurons coexpressed NKB in the ARC. Infusion of NKB for 2 h into the lateral ventricle elicited a discharge of LH, which resulted in significant increases in LH concentrations between 20 and 50 min after the start of infusion compared with a saline-infused control. Animals were sacrificed immediately after the end of infusion, and Fos expression in ARC kisspeptin neurons was immunohistochemically examined. The NKB treatment activated kisspeptin neurons throughout the ARC, and approximately 70% of kisspeptin neurons expressed Fos immunoreactivity at the caudal portion of the nucleus. The present study demonstrated that a central infusion of NKB elicited a discharge of LH, which was associated with the activation of a large population of ARC kisspeptin/NKB neurons in seasonally anestrous ewes. The results suggest that NKB plays a stimulatory role in the control of pulsatile GnRH secretion and that the population of ARC kisspeptin/NKB neurons is one of sites of the NKB action in sheep.

著者

• Ohkura Satoshi

  Laboratory Of Animal Production Science Graduate School Of Bioagricultural Sciences Nagoya Universit

• Takeuchi Yukari

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Wakabayashi Yoshihiro

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Mori Yuji

  Laboratory Of Veterinary Ethology Animal Resource Science The University Of Tokyo

• Okamura Hiroaki

  Laboratory Of Adaptation Physiology National Institute Of Animal Industry Ministry Of Agriculture Fo

• Yayou Ken-ichi

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• OHKURA Satoshi

  Laboratory of Animal Production Science, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan

• MURATA Ken

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan

• SAKAMOTO Kohei

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

• MORI Yuji

  Laboratory of Veterinary Ethology, The University of Tokyo, Tokyo 113-8657, Japan

• YAYOU Ken-ichi

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan

• OKAMURA Hiroaki

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences, Ibaraki 305-0901, Japan

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