The Mouse Putative Pheromone Receptor Was Specifically Activated by Stimulation with Male Mouse Urine.

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概要

• 論文の詳細を見る

• To detect the biological activity of mammalian putative pheromone receptors (V1Rs and V2Rs), the mouse V1R gene was introduced into a primary culture of vomeronasal cells using the adenovirus expression system, and the response of these cells to mouse urine was analyzed by calcium imaging. These cells specifically responded to male but not female mouse urine. This response was attenuated by pertussis toxin, a specific inhibitor of G-protein Giα/Goα coupling from receptors. Our findings indicate that a putative pheromone receptor was specifically activated by mouse urine, a major source of mouse pheromones, and suggest that Gi/Go are functionally coupled with the receptor.

• 社団法人 日本生化学会の論文

著者

• HAGINO-YAMAGISHI Kimiko

  Department of Ultrastructural Research, Tokyo Metropolitan institute of Medical Science

• ICHIKAWA Masumi

  CREST (Core Research for Evolutional Science and Technology), Department of Developmental Morphology

• Wakabayashi Yoshihiro

  Department Of Transplantation And Regenerative Surgery Graduate School Of Medicine Kyoto Prefectural

• Matsuoka Masato

  Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

• YAZAKI Kazumori

  Department of Ultrastructual Research, The Tokyo Metropolitan Institute of Medical Science

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

• HAGINO-YAMAGISHI Kimiko

  Department of Dementia and Higher Brain Function, Integrated Neuroscience Research Project, Tokyo Metropolitan Institute of Medical Science, 2–1–6 Kamikitazawa, Setagaya-ku, Tokyo 156–8506, Japan

• Wakabayashi Yoshihiro

  Department of Ultrastructural Research, Tokyo Metropolitan Institute of Medical Science

• Ichikawa Masumi

  CREST (Core Research for Evolutional Science and Technology), Department of Developmental Morphology, Tokyo Metropolitan Institute for Neuroscience

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