Sequences and Polymorphisms of the Canine Monoamine Transporter Genes SLC6A2, SLC6A3, and SLC6A4 among Five Dog Breeds(Ethology)

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概要

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• Monoamine transporters have roles to regulate the monoamine concentrations in synaptic clefts in the central nervous system and are the targets of antidepressants and psychostimulants. They include transporters for norepinephrine, dopamine and serotonin, which are encoded by the SLC6A2, SLC6A3, and SLC6A4 genes, respectivily. We sequenced the full lengths of the coding regions of these genes for dogs and identified four single nucleotide polymorphisms (SNPs) in SLC6A2 and four in SLC6A3. One SLC6A3 SNP was non-synonymous and caused an amino acid substitution from threonine to serine. The genotype frequencies of these polymorphisms differed significantly among five breeds with different behavioral traits, suggesting that novel SLC6A2 and SLC6A3 SNPs would provide additional useful information for behavioral genetic studies in dogs.

• 社団法人日本獣医学会の論文
• 2008-09-25

著者

• SHIMOZURU Michito

  Laboratory of Wildlife Biology, Graduate School of Veterinary Medicine, Hokkaido University

• MORI Yuji

  Laboratory of Veterinary Ethology, The University of Tokyo

• TAKEUCHI Yukari

  Laboratory of Veterinary Ethology, The University of Tokyo

• Mori Y

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Mori Yuji

  Univ. Tokyo Tokyo Jpn

• Mori Yuji

  Laboratory Of Veterinary Ethology The University Of Tokyo

• ARATA Sayaka

  Laboratory of Veterinary Ethology,The University of Tokyo

• OGATA Niwako

  Laboratory of Veterinary Ethology,The University of Tokyo

• Shimozuru Michito

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Ogata Niwako

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Takeuchi Yukari

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Mori Yuji

  Laboratory Of Veterinary Ethology Animal Resource Science The University Of Tokyo

• SHIMOZURU Michito

  Laboratory of Wildlife Biology and Medicine, Graduate School of Veterinary Medicine, Hokkaido University

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

• ARATA Sayaka

  Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

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