Central Administration of Neuropeptide B, But not Prolactin-Releasing Peptide, Stimulates Cortisol Secretion in Sheep

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概要

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• Two neuropeptides, neuropeptide B (NPB) and prolactin-releasing peptide (PrRP), have been suggested to play important roles in control of the hypothalamic-pituitary-adrenal (HPA) axis in rodents. The aim of the present study was to clarify the central actions of NPB or PrRP in sheep. Ovariectomized ewes were surgically implanted with a cannula directed to the lateral ventricle. They received intracerebroventricular (icv) administration of 400 μl of artificial cerebrospinal fluid, NPB (0.05, 0.5 or 5 nmol), PrRP (0.5, 5 or 50 nmol) or corticotropin-releasing hormone (CRH, 0.5 or 5 nmol) through the cannula, and blood samples were taken 30 and 0 min prior to and 15, 30, 60 and 90 min after the injection. Cortisol concentrations in plasma were determined by enzyme immunoassay. Administration of 0.5 nmol NPB resulted in a significant increase in the cortisol concentration compared with the vehicle control, whereas the cortisol concentration after lower or higher doses of NPB did not differ from the control value. Thus, an icv injection of NPB produced a bell-shaped dose-response of cortisol concentration. Administration of PrRP had no significant effect on the cortisol concentrations at any dose examined. Icv injection of CRH dose-dependently increased plasma cortisol concentrations. These results demonstrate that central NPB stimulates cortisol secretion, suggesting that this neuropeptide plays some roles in control of the HPA axis in sheep. On the other hand, unlike its role in rodents, PrRP is unlikely to be involved in control of the HPA axis in this species.

• 2008-04-01

著者

• OHKURA Satoshi

  Laboratory of neuro-endocrinology, National Institute of Agrobiological Sciences

• MOGI Kazutaka

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• ITO Shuichi

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• MATSUYAMA Shuichi

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• OHARA Hiromi

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• SAKUMOTO Ryosuke

  Laboratory of Reproductive Biology and Technology, National Institute of Agrobiological Sciences

• YAYOU Kenichi

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• SUTOH Madoka

  Laboratory of Growth Regulation, National Institute of Livestock and Grassland Science

• MORI Yuji

  Laboratory of Veterinary Ethology, The University of Tokyo

• OKAMURA Hiroaki

  Laboratory of Neurobiology, National Institute of Agrobiological Sciences

• Ohkura S

  Department Of Bioengineering Sciences Graduate School Of Bioagricultural Sciences Nagoya University

• Ohkura Satoshi

  Laboratory Of Animal Production Science Graduate School Of Bioagricultural Sciences Nagoya Universit

• Ohkura Satoshi

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Mori Y

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Okamura H

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Sutoh Madoka

  Laboratory Of Growth Regulation National Institute Of Livestock And Grassland Science

• Ohno Hiroaki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Mogi Kazutaka

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Yayou Kenichi

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Ohkura S

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Mori Yuji

  Univ. Tokyo Tokyo Jpn

• Mori Yuji

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Matsuyama S

  National Institute Of Livestock And Grassland Science National Agriculture And Food Research Organiz

• Matsuyama S

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Okamura Hiroaki

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Sakumoto Ryosuke

  Laboratory Of Reproductive Biology And Technology National Institute Of Agrobiological Sciences

• Ito Shuichi

  Laboratory Of Neurobiology National Institute Of Agrobiological Sciences

• Mori Yuji

  Laboratory Of Veterinary Ethology Animal Resource Science The University Of Tokyo

• Okamura Hiroaki

  Laboratory Of Adaptation Physiology National Institute Of Animal Industry Ministry Of Agriculture Fo

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

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