Naloxone Blocks the Deterioration of Male Sexual Behavior Induced by Alarm Pheromone in Rats

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概要

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• Previously, we have demonstrated that the alarm pheromone deteriorates sexual behavior in male rats, which was blocked by pretreatment with a corticotrophin-releasing hormone (CRH) antagonist. Studies have shown that an opioid antagonist blocked the deterioration of male sexual behavior following intracerebroventricular administration of CRH. Therefore, possibly, the pheromone effects could also be mediated by the opioid system. In this study, we pretreated rats with naloxone, an opioid receptor antagonist, and examined the following sexual behavior modulations in male rats that were exposed to the alarm pheromone. Naloxone blocked the deterioration of sexual behavior in a dose-dependent manner. On the basis of these data and the results of the previous study, we conclude that the alarm pheromone activates the CRH system, which then activates the opioid system, to deteriorate male sexual behavior.

著者

• ARATA Sayaka

  Laboratory of Veterinary Ethology,The University of Tokyo

• Takeuchi Yukari

  Laboratory Of Veterinary Ethology The University Of Tokyo

• Kobayashi Tatsuya

  Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U

• Mori Yuji

  Laboratory of Physical Chemistry Tokyo Institute of Technology

• TAKEUCHI Yukari

  Laboratory of Veterinary Ethology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

• KIYOKAWA Yasushi

  Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

• ARATA Sayaka

  Laboratory of Veterinary Ethology, Department of Animal Resource Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

• ARATA Sayaka

  Laboratory of Veterinary Ethology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

• KOBAYASHI Tatsuya

  Laboratory of Veterinary Ethology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1–1–1 Yayoi, Bunkyo-ku, Tokyo 113–8657, Japan

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