Postprandial Changes in Ornithine Decarboxylase Activity, and the Mucosal and Intraluminal Polyamine Levels in the SmalI Intestine of Rats Concerning the Significance of Intestinal Putrescine Absorption
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概要
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The dietary response of mucosal ornithine decarboxylase (ODC) in meal-fed and refed rats was investigated for each quarter of the small intestine. The intake of a normal powdered diet caused a considerable postprandial increase in the ODC activity in the mid two quarters, while the intragastric infusion of an aqueous solution containing amino acids and glucose elevated the ODC activity to a large extent in the proximal quarter as well as in its contiguous mid quarter. Such responsiveness was almost completely depressed by previous α-difluoromethylornithine (DFMO) administration. Mucosal scrapings from the small intestine of rats with ODC depression did not significantly differ from those without ODC depression as to their [^3H]thymidine-, [^3H]uridine-, and [^3H]leucine-incorporating capacity into the DNA, RNA, and protein fractions, respectively, at various postprandial times. On the other hand, putrescine was found to plentifully accumulate in the ileal lumen within a few hours after the start of eating, suggesting that the ODC depression would thereby have been compensated. To investigate this further, putrescine-uptake experiments were carried out with both everted sacs and in situ loops of the small intestine. It is assumed from the results that [^<14>C]putrescine was transported a little more across the ileal wall than across the duodenal or jejunal wall by a Na^+- or energy-independent mechanism, and that [^<14>C]putrescine taken up from the lumen distributed itself within the whole body.
- 社団法人日本農芸化学会の論文
- 1994-08-23
著者
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IWAMI Kimikazu
Laboratory of Molecular Nutrition, Kyoto Prefectural University
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Iwami Kimikazu
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Ibuki Fumio
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Terase Norihisa
Laboratory of Food and Nutritional Sciences, Department of Agricultural Chemistry, Kyoto Prefectural
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Kobayashi Tatsuya
Laboratory of Food and Nutritional Sciences, Department of Agricultural Chemistry, Kyoto Prefectural
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Terase Norihisa
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Iwami Kimikazu
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Kobayashi Tatsuya
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Ibuki Fumio
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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