Effects of Cys Mutation on Taurocholic Acid Transport by Mouse Ileal and Hepatic Sodium-dependent Bile Acid Transporters(Biochemistry & Molecular Biology)
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概要
- 論文の詳細を見る
All cysteines of mouse ileal and hepatic sodium-dependent bile acid transporters (Isbt and Ntcp, respectively) were individually replaced by alanine. Replacement of Cys^<106> in Isbt and Cys^<96> in Ntcp, which are located closely in alignment, decreased taurocholate uptake. Although Cys^<51> in Isbt is conserved in Ntcp, the replacement spoiled Isbt only. Both similarity and difference in the arrangement of functional sites are suggested.
- 社団法人日本農芸化学会の論文
- 2002-02-23
著者
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Saeki Tohru
Laboratory of Molecular Nutrition, Kyoto Prefectural University
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IWAMI Kimikazu
Laboratory of Molecular Nutrition, Kyoto Prefectural University
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KANAMOTO Ryuhei
Laboratory of Molecular Nutrition, Kyoto Prefectural University
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Iwami K
Lab. Of Molecular Nutrition Kyoto Prefectural Univ.
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Saeki Tohru
Laboratory Of Molecular Nutrition Department Of Biological Resource Chemistry Kyoto Prefectural Univ
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Iwami Kimikazu
Laboratory Of Food And Nutritional Sciences Department Of Agricultural Chemistry Kyoto Prefectural U
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Kanamoto R
Lab. Of Molecular Nutrition Kyoto Prefectural Univ.
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Kanamoto Ryuhei
Laboratory Of Molecular Nutrition Department Of Biological Resource Chemistry Kyoto Prefectural Univ
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Saeki Tohru
Laboratory Of Molecular Nutrition Kyoto Prefectural University
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KURODA Toshinori
Laboratory of Vital & Molecular Nutrition, Department of Biological Resource Chemistry, Faculty of A
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MATSUMOTO Makiko
Laboratory of Vital & Molecular Nutrition, Department of Biological Resource Chemistry, Faculty of A
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Kuroda Toshinori
Laboratory Of Vital & Molecular Nutrition Department Of Biological Resource Chemistry Faculty Of
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Matsumoto Makiko
Laboratory Of Vital & Molecular Nutrition Department Of Biological Resource Chemistry Faculty Of
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KANAMOTO Ryuhei
Laboratory of Food and Nutrition Department of Agricultural Chemistry, Kyoto Prefectural University
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