Effects of Heavy Metals on Mitogen-Activated Protein Kinase Pathways

スポンサーリンク

概要

• 論文の詳細を見る

• The signaling pathways leading to cellular protection or cell death following exposure to heavy metals have not been fully clarified. Mitogen-activated protein kinases (MAPKs), i.e., extracellular signal-regulated protein kinase (ERK), c-Jun NH_2-terminal kinase (JNK) and p38 MAPK transmit extracellular signals into the nucleus, and have been shown to participate in a diverse array of cellular functions such as cell growth, differentiation and apoptosis. Treatment with cadmium, inorganic mercury or tributyltin can activate ERK, JNK and p38 MAPK, and induces the expression of c-fos and c-jun genes prior to the development of apoptosis. However, the members of the MAPK family appear to be differentially activated depending on the heavy metal and the cell type exposed. Consequently, various cellular responses may be caused by the distinct pattern of MAPKs activation. MAPKs may be one of the important cellular signal transduction pathways affected by various environmental pollutants, including heavy metals.

• 日本衛生学会の論文

著者

• Igisu Hideki

  Department Of Environmental Toxicology Insitute Of Industrial And Ecological Sciences University Of

• Matsuoka M

  Research Laboratories Nippon Shinyaku Co. Ltd.

• Igisu H

  Univ. Occupational And Environmental Health Kitakyushu Jpn

• Matsuoka M

  Department Of Environmental Toxicology Institute Of Industrial Ecological Sciences University Of Occ

• Matsuoka Masato

  Department Of Neurobiology And Anatomy Niigata University School Of Medicine

• Matsuoka Masato

  Department of Environmental Toxicology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health

関連論文

• The Mouse Putative Pheromone Receptor Was Specifically Activated by Stimulation with Male Mouse Urine
• N-Acetylcysteine Fails to Protect Rats from Acrylamide Neurotoxicity
• Levels of Vascular Endothelial Growth Factor and Pigment Epithelium-Derived Factor in Eyes Before and After Intravitreal Injection of Bevacizumab
• Release of heat shock proteins from human neuroblastoma cells exposed to acrylamide
• Functional and Biochemical Evaluation of the Preserved Lung in a Rat Model
• Effects of Glucose on Rat Lung Preservation : Report of a Study Conducted on an Isolated Lung Reperfusion Model Utilizing Another Isolated Lung as a "Deoxygenator"
• Synthesis and Antibacterial Activity of Novel 7-Substituted-6-fluoro-1-fluoromethyl-4-oxo-4H-[1,3]thiazeto[3,2-α]quinoline-3-carboxylic Acid Derivatives
• Structure-Antibacterial Activity and Cytotoxicity Relationships of Thiazolo and Thiazetoquinolone Derivatives
• Expression of Pigment Epithelium-Derived Factor and Vascular Endothelial Growth Factor in Fibrovascular Membranes from Patients with Proliferative Diabetic Retinopathy
• Specific expression pattern of Fos in the accessory olfactory bulb of male mice after exposure to soiled bedding of females
• L-カルニチンによるマウスのペンチレンテトラゾール誘発けいれんおよび脳内c-fos発現の抑制
• Suppression of Pentylenetetrazol-Induced Seizures and c-fos Expression in Mouse Brain by _L-Carnitine
• Effects of Heavy Metals on Mitogen-Activated Protein Kinase Pathways
• The Mouse Putative Pheromone Receptor Was Specifically Activated by Stimulation with Male Mouse Urine.

もっと見る 閉じる

スポンサーリンク