Effects of Simultaneous Immunization of Haemophilus influenzae Type b Conjugate Vaccine and Diphtheria-Tetanus-Acellular Pertussis Vaccine on Anti-Tetanus Potencies in Mice, Guinea Pigs, and Rats

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概要

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• Haemophilus influenzae type b vaccine conjugated with tetanus toxoid (HibT) was licensed for use in childhood immunization in Japan in 2007. As adsorbed diphtheria-tetanus-acellular pertussis (DTaP) combined with HibT vaccine has not been introduced in Japan, DTaP and HibT vaccines are injected at separate sites with a similar immunization schedule. There are various interfering or stimulatory effects between components of combined vaccines contained in DTaP and HibT vaccines. In this study, we investigated the effect of HibT containing combination vaccines on anti-tetanus potencies by using animal models (mouse, guinea pig, and rat). HibT vaccine and HibT components of imported DTaP-HibT vaccine alone showed comparable or higher anti-tetanus potency than DTaP vaccine and DTaP-containing components of combination vaccines. Mixing these components before injection resulted in potencies greater than the sum of individual potencies. Injecting individual components at separate sites in animals resulted in potency roughly equivalent to the sum of the individual potencies. These results provide useful information regarding the use of HibT-containing multivalent vaccines in childhood immunization.

著者

• Nakashima Hideki

  Department Of Advanced Energy Engineering Science Interdisciplinary Graduate School Of Engineering S

• Iwaki Masaaki

  Department Of Pharmacology Faculty Of Veterinary Science Chulalongkorn University

• Shibayama Keigo

  Department Of Bacterial Pathogenesis And Infection Control National Institute Of Infectious Diseases

• Fukuda Tadashi

  Department Of Civil Engineering Tohoku University

• Takahashi Motohide

  Department of Bacteriology II, National Institute of Infectious Diseases

• Nakashima Hideki

  Department of Microbiology, St. Marianna University of Medicine

• Komiya Takako

  Department of Bacteriology II, National Institute of Infectious Diseases

• Fukuda Tadashi

  Department of Bacteriology II, National Institute of Infectious Diseases

• Iwaki Masaaki

  Department of Bacteriology II, National Institute of Infectious Diseases

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