Oxidative Stress Induces Phosphoenolpyruvate Carboxykinase Expression in H4IIE Cells
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概要
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Oxidative stress is closely associated with diabetes and is a major cause of insulin resistance. Impairment of hepatic insulin action is thought to be responsible for perturbations in hepatic glucose metabolism. In this study, we found that oxidative stress is involved in the dysregulation of gene expression of phosphoenolpyruvate carboxykinase (PEPCK), a key gluconeogenic enzyme, by a mechanism independent of insulin. Elevation of oxidative stress by injection of ferric nitrilotriacetate in rats increased the expression of hepatic PEPCK mRNA. To examine the direct action of oxidative stress on PEPCK expression, we treated H4IIE hepatoma cells with buthionine sulfoximine (BSO), an inhibitor of glutathione synthesis. BSO increased intracellular oxidative stress and the expression of PEPCK mRNA. Inhibition of p38 mitogen-activated protein kinase (p38 MAP kinase), which mediates responses to oxidative stress, suppressed the induction of PEPCK mRNA by BSO. These results suggest that oxidative stress dysregulates hepatic PEPCK expression by an insulin-independent mechanism.
- 2007-09-23
著者
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Nagasawa Takashi
Depatment Of Biological Chemistry And Food Sciences Faculty Of Agriculture Iwate University
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ITO Yoshiaki
Food and Health Science, Faculty of Agriculture, Iwate University
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OUMI Saori
Food and Health Science, Faculty of Agriculture, Iwate University
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NAGASAWA Takashi
Food and Health Science, Faculty of Agriculture, Iwate University
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NISHIZAWA Naoyuki
Food and Health Science, Faculty of Agriculture, Iwate University
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ITO Yoshiaki
Department of Agro-Bioscience, Faculty of Agriculture, Iwate University
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HASE Sumihiro
Department of Chemistry, Graduate School of Science, Osaka University
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ISHIMIZU Takeshi
Department of Chemistry, Osaka University Graduate School of Science
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Oumi Saori
Food And Health Science Faculty Of Agriculture Iwate University
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Ishimizu Takeshi
Department Of Chemistry Graduate School Of Science Osaka University
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Nagasawa Takashi
Food And Health Science Faculty Of Agriculture Iwate University
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Hase Sumihiro
Department Of Chemistry Graduate School Of Science Osaka University
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Nagasawa T
Depatment Of Biological Chemistry And Food Sciences Faculty Of Agriculture Iwate University
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OHASHI Takao
Department of Life Sciences, Faculty of Agriculture, Kagawa University
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Ohashi Takao
Department Of Chemistry Graduate School Of Science Osaka University
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AKITA Kazumasa
Department of Chemistry, Graduate School of Science, Osaka University
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Akita Kazumasa
Department Of Chemistry Graduate School Of Science Osaka University
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Ohashi Takao
Department Of Bioscience & Biotechnology Faculty Of Agriculture Kyushu University
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NAGASAWA Takashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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Oumi Saori
Department of Chemistry, Graduate School of Science, Osaka University
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