Effects of Dietary Korean Proso-Millet Protein on Plasma Adiponectin, HDL Cholesterol, Insulin Levels, and Gene Expression in Obese Type 2 Diabetic Mice

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概要

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• We investigated the effect of dietary Korean proso-millet protein concentrate (PMP) on glycemic responses, plasma lipid levels, and the plasma level and gene expression of adiponectin in obese type 2 diabetic mice under normal and high-fat feeding conditions. The findings were that the feeding of PMP clearly elevated plasma high-density lipoprotein cholesterol (HDL cholesterol) and adiponectin levels and brought about effective reduction in the levels of glucose and insulin in mice under high-fat diet conditions as compared with a control diet. Gene expression study revealed that the diet up-regulated expression of adiponectin and down-regulated tumor necrosis factor-α (TNF-α). Considering the central role of adiponectin and HDL cholesterol in improving and ameliorating type 2 diabetes, obesity, and cardiovascular disease, our findings imply that PMP may have potential for therapeutic intervention in type 2 diabetes.

著者

• ITO Yoshiaki

  Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University

• NISHIZAWA Naoyuki

  Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University

• NAGASAWA Takashi

  Biological Chemistry and Food Sciences, Faculty of Agriculture, Iwate University

• CHOI Myeong-Rak

  Division of Biotechnology and Chemical Engineering, Yosu National University

• Nagasawa Takashi

  Food And Health Science Faculty Of Agriculture Iwate University

• Nagasawa T

  Depatment Of Biological Chemistry And Food Sciences Faculty Of Agriculture Iwate University

• PARK Kyung-Ok

  United Graduate School of Agricultural Sciences, Iwate University

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