The Effect of Insulin on Myofibrillar Protein Degradation in Normal and Streptozotocin-induced Diabetic Rats Measured by the Rate of Nτ-Methylhistidine Release from Perfused Hindquarters
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概要
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Myofibrillar protein degradation was measured by the rate of Nτ-methylhistidine (MeHis) release from the-perfused hindquarters in normal and streptozotocin-induced diabetic rats. In diabetic rats, the rate of MeHis release to the perfusate was elevated 2-fold compared with normal rats. The daily excretion of MeHis into urine was also increased 2-fold in the diabetic rats. Insulin in the perfusate did not suppress the release of MeHis from the perfused muscle in normal rats. On the other hand, in diabetic rats, MeHis release was suppressed by insulin. The high concentration of free MeHis in the diabetic muscle was decreased to the normal level with insulin added to the perfusate. These results give further evidence to show that myofibrillar protein degradation is controlled by insulin.
- 社団法人 日本農芸化学会の論文
著者
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Naito Hiroshi
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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NOGUCHI Tadashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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KADOWAKI Motoni
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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NAGASAWA Takashi
Department of Agricultural Chemistry, Faculty of Agriculture, The University of Tokyo
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