Some Nutritional and Physiological Factors Affecting the Urinary Excretion of Acid Soluble Peptides in Rats and Women

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Urinary excretion of acid soluble peptide (ASP)-form amino acids was lower in rats deprived of protein than in rats fed on a 20% casein or 20% gluten diet. However, the amino acid pattern of urinary ASP was similar among each of the three dietary groups, suggesting that urinary ASP is mainly endogenous origin under these nutritional conditions. College women who were given a meat-free protein diet for 3 days after 10 days protein deprivation excreted 1.4 times the amount of ASP-form amino acids during protein deprivation. The rate of urinary excretion of ASP-form amino acids in the state of protein deprivation was proportional to the metabolic body size of organisms as far as rats and women were concerned. Streptozotocin-induced diabetic rats excreted two times the amount of ASP-form amino acids compared with normal rats. This suggests that endogenous protein catabolism doubled in diabetic rats. When labelled urinary ASP was injected into rats, approximately 40% of the label was recovered as urinary ASP within 24hr. This excretion rate was far higher than that after the injection of free leucine. The rate of urinary excretion of ASP-form amino acids correlated with that of Nτ-methylhistidine in rats. These results favor the hypothesis that urinary ASP reflects the catabolism of body proteins.
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