Quantitative Significance of Plasma Albumin Metabolism in the Whole Body Protein Turnover in Rats

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The amount of extra- and intravascular albumin was estimated in two groups of rats, i. e., those fed a 20% casein (20% protein) diet and a 3% casein (low protein or 3% protein) diet. The fractional turnover rate of whole body plasma albumin was also measured in the two groups of rats, employing the constant infusion method of Waterlow et al. At the same time, the fractional turnover rate of the whole body protein was measured. When the diet was changed from the 20% protein to the 3% protein diet, the amount of albumin mass in both extra- and intravascular spaces decreased significantly. During 7 days on the diet, the extra- and intravascular albumin mass per 100g of body weight did not change significantly in the rats fed the 20% protein diet. On the other hand, rats fed the 3% protein diet lost almost 30%of the extra- and intravascular albumin per 100g body weight. The fractional turnover rates of whole body albumin were estimated to be 31.7 and 19.8%/day in the 20% protein and the 3% protein diet-fed rats, respectively. The fractional turnover rates of whole body protein were 16.1 and 10.6%/day in the 20% protein and the 3% protein diet-fed rats, respectively. The leucine fluxes to albumin synthesis and whole body protein synthesis were calculated to be 5.9 and 83μmol/hr, respectively, in the 20% protein diet-fed rats. The leucine fluxes in the 3% protein diet-fed rats were 2.5 and 54μmol/hr for the albumin synthesis and for the whole body protein synthesis, respectively. These results demonstrate the quantitative significance of albumin metabolism in the whole body protein turnover in rats fed on two levels of protein intake.
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Quantitative Significance of Plasma Albumin Metabolism in the Whole Body Protein Turnover in Rats

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