生薬製剤の薬物学的特性(第VIII報) : 多形核白血球遊走能に対する排膿湯,排膿散および桔梗の作用

概要

論文の詳細を見る
"Haino-san" and "Haino-to" are Chinese medicinal prescriptions used for the treatment of suppurative disease. In this paper "Haino-san," "Haino-to" and platycodon extract were tested for their effect on chemotaxis of polymorphonuclear (PMN) leucocyte in vitro and in vivo by Boyden's method. The results clearly showed that these two Chinese prescriptions and platycodon extract inhibited chemotaxis of PMN leucocyte. These inhibitory effects on chemotaxis of PMN leucocyte were found to be associated with generalized cell damage as defined by the ability of leucocyte to exclude trypan blue. When tested by carboxymethyl cellulose (CMC) pouch method, "Haino-san" and "Haino-to" inhibited the emigration of PMN leucocyte while platycodon extract accerelated their emigration. "Haino-san" inhibited leucocyte infiltration when tested on inflammation induced by intraperitoneal injection of casein sodium in mice. "Haino-san" and "Haino-to" were thus shown to have marked in vitro inhibitory effect on chemotaxis of PMN leucocyte and only very slight in vivo inhibitory effect on the emigration of PMN leucocyte.
日本生薬学会の論文
1983-03-20