Cholesterol Biosynthesis Inhibitory Component from Zingiber officinale ROSCOE
スポンサーリンク
概要
- 論文の詳細を見る
We previously reported on the isolation and identification of (E)-8β, 17-epoxylabd-12-ene-15,16-dial (ZT) from ginger (rhizome of Zingiber officinale ROSCOE, Zingiberaceae).In this paper, the pharmacological effects of ZT are reported. The experimental mouse hypercholesterolemia induced by Triton WR-1339 was treated after oral administration of ZT. In homogenated rat liver with ZT, cholesterol biosynthesis was decreased. In addition, the same activity was observed in the homogenated rat liver which was resected after the oral administration of ZT.According to the results of general pharmacological screening, no remarkable activity of ZT was observed except for an inhibitory effect on the cholesterol biosynthesis.
- 社団法人日本薬学会の論文
- 1993-04-15
著者
-
鹿野 美弘
北海道薬科大学
-
斉藤 謙一
北海道薬科大学
-
斎藤 謙一
北海道薬科大学
-
田部 昌弘
Nagakura Pharmaceutical Company Ltd.
-
陳 玉盤
Brion Research Institute of Taiwan
-
斎藤 謙一
Institute of Pharmaceutical Sciences
-
鹿野 美弘
Institute of Pharmaceutical Sciences
関連論文
- Pharmacological Properties of Galenical Preparation. XVI. Pharmacokinetics of Evodiamine and the Metabolite in Rats
- Pharmacological Properties of Galenical Preparation. XV. Pharmacokinetics Study of Evocarpine and Its Metabolite in Rats
- Pharmacological Properties of Galenical Preparation. XIV. Body Temperature Retaining Effect of the Chinese Traditional Medicine, "Goshuyu-to(呉茱萸湯)" and Component Crude Drugs
- 漢方エキス製剤の品質評価について(第6報)呉茱萸の修治によるアルカロイド成分含量変化について
- Polyacetylene Compounds from Atractylodes Rhizome
- A New Polyacetylene Compound from Atractylodes Rhizome
- 細辛精油 methyleugenol の吸収と排泄 : 呼吸器
- Cholesterol Biosynthesis Inhibitory Component from Zingiber officinale ROSCOE
- ISOLATION AND STRUCTURE ELUCIDATION OF NEW ALKALOIDS FROM FRITILLARIA DELAVAYI FRANCH
- COMPOSITE CONSTITUENT : NOVEL TRITERPENOID, IXERENOL, FROM AERIAL PARTS OF IXERIS CHINENSIS
- COMPOSITE CONSTITUENT : NOVEL TRITERPENOID, 17-EPI-LUPENYL ACETATE, FROM AERIAL PARTS OF IXERIS CHINENSIS
- P-92 冠心II号方とワルファリンの薬物相互作用に関する研究
- Mouse Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein is an Acute Phase Protein Induced by Inflammation
- 生薬「猪苓」標準化のための指標成分の探索
- 29A-06 風邪症候群に用いる漢方処方の生理学的検討
- P-9 上気道疾患に用いる漢方処方の作用特性について
- P-24 寒熱証測定装置の開発と漢方薬物の作用について
- Enzyme Inhibitory Activities of Acetylene and Sesquiterpene Compounds in Atractylodes Rhizome
- 証を念頭に置いた基礎研究の可能性を探る
- Effects of Dexamethasone and Aminophylline on Survival of Jurkat and HL-60 Cells(Pharmacology)
- ラット及びヒトへの葛根湯(Ge-Gen-Tang)経口投与による尿中排泄成分について
- Urinary and Biliary Metabolites of Puerarin in Rats
- ラットへの葛根主要成分経口投与による体内動態
- Urinary and Biliary Metabolites of Daidzin and Daidzein in Rats
- Three New Neolignans, Fargesones A, B and C, from the Flower Buds of Magnolioa fargesii
- Efficient Production of 2-Deoxyribose 5-Phosphate from Glucose and Acetaldehyde by Coupling of the Alcoholic Fermentation System of Baker's Yeast and Deoxyriboaldolase-Expressing Escherichia coli
- Pharmacological Properties of Traditional Medicine (XXIX) : Effect of Hange-shashin-to and the Combinations of Its Herbal Constituents on Rat Experimental Colitis(Pharmacognosy)
- 北海道産生薬の生薬植物学的研究-8-エゾエンゴサクの栽培-4-3年度植物から6年度植物について
- Pharmacognostical and Botanical Studies on the Crude Drugs in Hokkaido-9-Cultivation of Corydalis ambigua Cham.et Schlecht-5-Annual Variation of Alkaloid Contents
- 漢方方剤「排膿散」中の枳実および芍薬成分(naringin,neohesperidin,paeoniflorin)の定量
- 生薬製剤の薬物学的特性-4-黄色ブドウ球菌226株によるマウスの膿瘍に対する排膿湯および排膿散の作用
- Simultaneous Doping Analysis of Main Urinary Metabolites of Anabolic Steroids in Horse by Ion-trap Gas Chromatography-Tandem Mass Spectrometry
- Characterization and Quantification of Fluoxymesterone Metabolite in Horse Urine by Gas Chromatography/Mass Spectrometry
- Stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry for measurement of phenolic xenoestrogens in human urine samples
- 漢方エキス製剤の品質評価について-1-「生姜」中の6-gingerol
- Effects of the Acetylene Compound from Atractylodes Rhizome on Experimental Gastric Ulcers Induced by Active Oxygen Species
- Development of Miniaturized Hollow-fiber Assisted Liquid-phase Microextraction with in situ Acyl Derivatization Followed by GC-MS for the Determination of Benzophenones in Human Urine Samples
- Measurement of Benzophenones in Human Urine Samples by Stir Bar Sorptive Extraction and Thermal Desorption-Gas Chromatography-Mass Spectrometry
- Determination of Benzophenones in River-water Samples Using Drop-based Liquid Phase Microextraction Coupled with Gas Chromatography/Mass Spectrometry
- Analysis of glutathione and glutathione disulfide in human saliva using hydrophilic interaction chromatography with mass spectrometry
- 29D-07 遠志と酸棗仁の複合効果に関する研究
- 生薬製剤の薬物学的特性-11-高速液体クロマトグラフ法によるラット尿および胆汁中の粉防已成分Tetrandrineの定性と定量
- 漢方エキス製剤の品質評価について-4-〔6〕-gingerolおよび〔6〕-shogaolの定量と移行率
- 漢方エキス製剤の品質評価について-3-小半夏加茯苓湯における「半夏」の指標物質
- Hollow-fiber-supported liquid phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for determination of chlorophenols in human urine samples
- Determination of urinary triclosan by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry
- Chromatographic and mass spectrometric analysis of glutathione in biological samples
- Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample
- Miniaturized hollow fiber assisted liquid-phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for analysis of bisphenol A in human urine sample
- 1. 薬物の反応特性と証解析(証を念頭に置いた基礎研究の可能性を探る, 第56回日本東洋医学会学術総会)
- 薬物の反応特性と証解析(シンポジウム1「証を念頭に置いた基礎研究の可能性を探る」, 第56回日本東洋医学会学術総会)
- Highly Sensitive Reporter Gene Assay for Dioxins in Human Plasma by Using Cycloheximide as an Enhancer Substance
- 生薬製剤の薬物学的特性-7-マウス皮内膿瘍に対する排膿散構成生薬の作用
- 漢方エキス製剤の品質評価について(第8報) : 3D-HPLCによる白朮アセチレン化合物の比較分析
- Application of a novel large-volume injection method using a stomach-shaped inlet liner in capillary gas chromatographic trace analysis of dioxins in human milk and plasma
- Epigenetic Assessment of Environmental Chemicals Detected in Maternal Peripheral and Cord Blood Samples
- 漢方エキス製剤の品質評価について(第3報) : 小半夏加茯苓湯における「半夏」の指標物質
- 菱の抗菌活性成分について
- Disease-dependent Differently Methylated Regions (D-DMRs) of DNA are Enriched on the X Chromosome in Uterine Leiomyoma
- 和産「金時ショウガ」の精油成分の季節変動
- 和産「金時ショウガ」の生育ならびに辛味成分とジテルペン成分について
- 北海道産生薬の生薬植物学的研究(第6報) : エゾエンゴサクの栽培(その2) : 発芽(補遺)ならびに植物の更新について
- 北海道産生薬の生薬植物学的研究(第3報) : エゾエンゴサクの栽培(その1) : 発芽と初年度植物について
- 漢方方剤「排膿散」中の枳実および芍薬成分(naringin, neohesperidin, paeoniflorin)の定量
- 北海道産生薬の生薬植物学的研究(第2報) : 道内産エゾムラサキツツジと中国産「満山紅」の生薬学的研究
- 生薬製剤の薬物学的特性(第VII報) : マウス皮内膿瘍に対する排膿散構成生薬の作用
- 生薬製剤の薬物学的特性(第IV報) : 黄色ブドウ球菌226株によるマウスの膿瘍に対する排膿湯および排膿散の作用
- 漢方エキス製剤の品質評価について(第2報) : 「乾姜」中の[6]-shogaol
- 「年会一般講演の座長のあり方」のパネルを読んで : その3
- 生薬製剤の薬物学的特性(第VIII報) : 多形核白血球遊走能に対する排膿湯,排膿散および桔梗の作用
- 北海道産生薬の生薬植物学的研究(第8報) : エゾエンゴサクの栽培(その4) 3年度植物から6年度植物について
- 漢方エキス製剤の品質評価について(第4報) : [6]-gingerolおよび[6]-shogaolの定量と移行率
- 生薬製剤の薬物学的特性(第XI報) : 高速液体クロマトグラフ法によるラット尿および胆汁中の粉防巳成分Tetrandrineの定性と定量
- 漢方エキス製剤の品質評価について(第1報) : 「生姜」中の6-gingerol