Synergistic Stimulation of Prostaglandin E2 Release by Epidermal Growth Factor and a Tumor Promoter Anthralin from Primary Cultures of Mouse Epidermal Cells.
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概要
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The tumor promoter anthralin stimulated prostaglandin E<SUB>2</SUB> (PGE<SUB>2</SUB>) and arachidonic acid release from primary cultures of mouse epidermal cells. Epidermal growth factor (EGF) hardly stimulated PGE<SUB>2</SUB> release by itself; however, a combination of anthralin and EGF synergistically stimulated PGE<SUB>2</SUB> release. Neither anthralin, EGF nor EGF plus anthralin affected the incorporation of arachidonic acid into cellular phospholipids at least up to 2 hr after the stimulation by these agents. In the presence of EGF, however, [<SUP>3</SUP>H]arachidonic aicd in the medium decreased substantially 4 -8 hr after the addition of this agent, indicating that EGF suppresses [<SUP>3</SUP>H]arachidonic acid release and stimulates the incorporation of [<SUP>3</SUP>H]arachidonic acid into the cells during this time period. Cellular cyclooxygenase activity was increased by treating the cells either with anthralin or EGF, and it was synergistically increased by EGF plus anthralin. Both cycloheximide and actinomycin D inhibited the increase in cyclooxygenase activity caused by EGF plus anthralin. These results indicate that the synergistic stimulation of PGE<SUB>2</SUB> release caused by EGF plus anthralin is due to a synergistic stimulation of arachidonic acid release (in the early phase of stimulation) and a synergistic increase in cyclooxygenase activity, probably a synergistic induction of cyclooxygenase, by these agents.
- 公益社団法人 日本薬理学会の論文
著者
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Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
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Nishikawa Kiyotaka
Department Of Clinical Pharmacology Research Institute International Medical Center Of Japan:presto
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Yamamoto Satoshi
Department Of Biochemistry Nagoya University School Of Medicine
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Aizu Eriko
Department of Pharmacology, School of Medicine, Keio University
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