Beneficial Circulatory Effect of L-Arginine.
スポンサーリンク
概要
- 論文の詳細を見る
L-Arginine is an essential amino acid for infants and growing children. This amino acid is a substrate for at least five enzymes identified in mammals, including arginase, arginine-glycine transaminase, kyotorphine synthase, nitric oxide synthase (NOS) and arginine decarboxylase. L-Arginine exerts antihypertensive and antiproliferative effects on vascular smooth muscles. NOS and arginine decarboxylase appear to be important for the effect of L-arginine on the circulatory system, since each produces nitric oxide (NO), a potent vasodilator, and agmatine, an endogenous noncatecholamine ligand for central alpha-2 adrenoceptors, from L-arginine. Several issues must be clarified before the mechanisms by which L-arginine exerts its effects on the circulatory system can be fully understood.
- 公益社団法人 日本薬理学会の論文
著者
-
Kato Ryuichi
Department Of Biology Graduate School Of Science Osaka University
-
Nakaki Toshio
Department Of Pharmacology Keio University School Of Medicine
-
NAKAKI Toshio
Department of Pharmacology, School of Medicine, Keio University
関連論文
- Crystallization and Preliminary X-Ray Crystallographic Studies of Thermus thermophilus HB8 MutM Protein Involved in Repairs of Oxidative DNA
- MACROMOLECULAR BINDING OF CARCINOGENIC/MUTAGENIC N- HYDROXYARYLAMINES THROUGH O-ACETYLATION PATHWAY
- MECHANISM OF MUTATION AND METABOLIC ACTIVATION OF NITRO-, NITROSO-, HYDROXYLAMINO-COMPOUNDS IN NITRO-COMPOUNDS RESISTANT MUTANTS OF AMES TESTAR STRAIN (TA98NR, TA98/1,8-DNP_6)
- Modulation of Ethanol-Mediated CYP2E1 Induction by Clofibrate and L-Carnitine in Rat Liver
- Formation of 2-Amino-3-methylimidazo[4,5-f]quinoline- and 2-Amino-3, 8-dimethylimidazo[4,5-f]quinoxaline-sulfamates by cDNA-expressed Mammalian Phenol Sulfotransferases
- CLONING, EXPRESSION, AND FUNCTIONAL CHARACTERIZATION OF RAT AND HUMAN PHENOL SULFOTRANSFERASES
- RAT LIVER SULFOTRANSFERASE ACTIVATING CARCINOGENIC HYDROXYMETHYL-ARENES : ITS PROPERTIES AND SEQUENCE ANALYSIS OF cDNA
- MECHANISM OF THE CHANGES IN HEPATIC DRUG METABOLIZING ENZYMES IN DIABETIC STATES
- REGULATION AND CHARACTERIZATION OF STEROID 6β-HYDROXYLASE IN RAT LIVERS
- ROLE OF GROWTH HORMONE ON THE EXPRESSION OF SEX-SPECIFIC FORMS OF CYTOCHROME P-450,P-450-MALE AND P-450-FEMALE
- STUDIES ON SEX-SPECIFIC FORMS OF CYTOCHROME P-450 IN MALE AND FEMALE RATS
- Regulation of Neuronal Glutathione Synthesis
- An Aspartate Aminotransferase from an Extremely Thermophilic Bacterium, Thermus thermophilus HB8^1
- Clinical course linkage among different priapism subtypes : Dilemma in the management strategies
- Nitric Oxide Is lmportant for Mouse Beta-Cell Line Killing by Peritoneal Exudate Cells Obtained from Cyclophosphamide Treated Non-Obese Diabeitc Mice
- Crystal Structure of Thermus thermophilus HB8 UvrB Protein, a Key Enzyme of Nucleotide Excision Repair
- Cloning and characterization of the radA gene from a hyperthermophilic archaeon Pyrobaculum islandicum.
- Quantitative Analysis of Three-dimensional Fatigue Fracture Surface Reconstructed by Stereo Matching Method
- Automated Image Processing and Analysis of Fracture Surface Patterns Formed during Creep Crack Growth in Austenitic Heat-Resisting Steels with Different Microstructures
- STEREOSELECTIVE HYDROXYLATION OF MEPHENYTOIN IN HUMAN LIVERS : CLONING AND EXPRESSION OF MEPHENYTOIN HYDROXYLASE cDNAS IN YEASTS AND THE GENETIC POLYMORPHISM
- S-5 CURRENT TOPICS OF SPECIES SPECIFICITY IN DRUG TOXICITY-METABOLIC ASPECT
- Changes in Cerebral Oxygen Saturation and Blood Flow During Hypoxic Gas Ventilation Therapy in HLHS and CoA/IAA Complex With Markedly Increased Pulmonary Blood Flow
- TOXICOLOGICAL SIGNIFICANCE OF A FORM OF CYTOCHROME P-450 HIGHLY PURIFIED FROM LIVER MICROSOMES OF PCBTREATED RATS : CATALYTIC AND IMMUNOCHEMICAL EXAMINATIONS OF A HIGH SPIN FORM OF CYTOCHROME P-448
- The Role of Glutathione in the Activation and Detoxication of a Naturally Occurring Mutagen-Carcinogen, Trp-P-2 (Regular Presentations) (Proceedings of the 10 th Symposium on Environmental Pollutants and Toxicology)
- MECHANISMS INVOLVED IN THE COVALENT BINDING OF A TRYPTOPHAN-PYROLYSATE PROMUTAGEN, TRP-P-2,TO DNA
- STUDIES ON CYTOCHROME P-450 RESPONSIBLE FOR THE OCCURRENCE OF SEX DIFFERENCE OF DRUG METABOLISM IN THE RAT
- A SENSITIVE METHOD FOR THE DETERMINATION OF BIPHENYL HYDROXYLASE ACTIVITY AND IT'S TOXICOLOGICAL APPLICATION
- MECHANISMS OF METABOLIC ACTIVATION OF A TRYPTOPHAN PYROLYSATE, 3-AMINO-1-METHYL-5H-PYRIDO [4,3-b] INDOLE
- PURIFICATION AND PROPERTIES OF CYTOCHROME P-450 AND NADPH-CYTOCHROME C (P-450) REDUCTASE FROM MICROSOMES OF HUMAN LIVERS
- STUDIES ON THE METABOLIC ACTIVATION AND THE MECHANISM OF TOXICITY OF DRUGS V. REDUCTION OF N-HYDROXY DERIVATIVE OF AN AROMATIC AMINE, 2-ACETYLAMINOFLUORENE BY CYTOCHROME P-450 (The 6th Meeting for the Study of Toxic Effect)
- DEGRADATION OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE (The 5th Meeting for the Study of Toxic Effect)
- Efficacy of a 14-day course of oral ciprofloxacin therapy for acute uncomplicated pyelonephritis
- Nerve injury-related erectile dysfunction following nerve-sparing radical prostatectomy : A novel experimental dissection model
- Alteration of glial cell line-derived neurotrophic factor family receptor alpha-2 mRNA expression and its co-expression with neuronal nitric oxide synthase in pelvic ganglia following unilateral cavernous nerve injury
- Outcome analysis for conservative management of Peyronie's disease
- Erectile dysfunction following nerve-sparing radical retropubic prostatectomy and its treatment with sildenafil
- Erosion of a penile prosthesis due to an indwelling urethral catheter as a late complication
- The correlation between penile tumescence measured by the erectometer and penile rigidity by the RigiScan
- A Case of Chronic Infantile Neurological Cutaneous Articular (CINCA) Syndrome with Marked Growth Disturbance
- Downregulation of immunomodulator gene expression in LPS-stimulated human polymorphonuclear leukocytes by the proton pump inhibitor lansoprazole
- Fractal Dimension of Grain-boundary Fracture for Characterization of High-temperature Fracture in Heat-resistant Alloys
- Quantitative Evaluation of the Impact Fracture Surfaces of SS400 Steel by the Three-dimensional Geometrical Analysis
- Suppression of phosphorylation of extracellular-signal-regulated kinase and p38 mitogen-activated protein kinase in polymorphonuclear leukocytes by the proton pump inhibitor lansoprazole
- Fractal Analysis of Fracture Surfaces in Materials Crept at High Temperatures or Fatigued by Repeated Bending
- Change in the Fracture Surface Pattern in the Fracture Process of SUS631 Stainless Steel Fatigued by Repeated Bending
- Characterization of Insulin-Dependent Diabetes Mellitus Induced by a New Variant (DK-27) of Encephalomyocarditis Virus in DBA/2 Mice
- TOXICOKINETICS:ITS SIGNIFICANCE AND PRACTICAL PROBLEMS
- Nitration Modifying Function of Proteins, Hormones and Neurotransmitters
- Possible involvement of cyclic AMP as an inhibitory regulator in thrombocyte aggregation induced by collagen in carp Cyprinus carpio
- A new chemical reaction of nitric oxide with norepinephrine in mammalian brain yielding 6-nitronorepinephrine
- Further Studies on the Persistence of Neonatal Androgen Imprinting on Sex-Specific Cytochrome P-450, Testosterone and Drug Oxidations
- Effects of Hypophysectomy and Growth Hormone Treatment on Sex-Specific Forms of Cytochrome P-450 in Relation to Drug and Steroid Metabolisms in Rat Liver Microsomes
- METABOLIC FATE OF FEPRAZONE
- EFFECTS OF α- AND β-ADRENERGIC BLOCKERS ON CHLORPROMAZINE-INDUCED ELEVATION OF PLASMA GLUCOSE AND CYCLIC AMP IN FED MICE
- EFFECT OF CHLORPROMAZINE ON INSULIN RELEASE IN MICE: COMPARISON BETWEEN IN VIVO AND IN VITRO
- AN UNUSUAL METABOLITE OF TESTOSTERONE BY CYTOCHROME P-450
- Anthralin, a Non-TPA Type Tumor Promoter, Synergistically Enhances Phorbol Ester-Caused Prostaglandin E2 Release from Primary Cultured Mouse Epidermal Cells
- Inhibitory Regulation of Serum Factor(s)-Caused Ornithine Decarboxylase Induction by the Protein Kinase C System in A431 Human Epidermoid Carcinoma Cells
- Mechanism of Thyroxine-induced Increase in Steroid Δ4-Reductase Actiyity in Male Rats
- Effect of Adrenalectomy on the Substrate Interaction with Cytochrome P-450 in the Hydroxylation of Steroid Hormones by Liver Microsomes
- PARTIAL AGONISTIC ACTION OF MORPHINE IN THE RAT VAS DEFERENS
- TOXICITY OF PLATINUM COMPLEXES WITH ANTITUMOR ACTIVITY (I)
- INHIBITION BY SKF 525-A OF 7-ETHOXYCOUMARIN O-DEETHYLATION IN MICROSOMAL AND THE RECONSTITUTED MONOOXYGENASE SYSTEMS FROM PCB-TREATED RAT LIVERS
- SA-06-2(013) Size Distribution of Creep Cracks and Fracture Mechanisms in High-Temperature Materials(Flaw Assessment at Elevated Temperature 1)
- PREVENTION OF CATECHOLAMINE RELEASE FROM ADRENAL CHROMAFFIN CELLS BY PHOSPHOLIPASE A2- AND LIPOXYGENASE-INHIBITORS
- Activation of Phorbol Ester Responsive Form of Protein Kinase CC in Association with Ca^ : Induced Differentiation of Primary Cultured Mouse Epidermal Cells
- Effect of Androgen and Estrogen on the Hydroxylation of Steroid Hormones by Rat Liver Microsomes
- Expression and Functional Characterization of a Rat Sulfotransferase (ST1A1)cDNA for Sulfations of Phenolic Substrates in COS-1 Cells
- Microstructures of Cutting Chips of SUS430 and SUS304 Steels, and NCF 750 and 6061-T6 Alloys
- THE APPARENT LOSS OF CYTOCHROME P-450 ASSOCIATED WITH METABOLIC ACTIVATION OF CARBON TETRACHLORIDE
- Plasma cyclic AMP in the pethidine-dependent rat.
- Hepatic level of mRNA in relation to polymorphism and strain difference in expression of cytochrome P-450g.
- Effect of Systemic L-Arginine Administration on Hemodynamics and Nitric Oxide Release in Man.
- Dexamethasone Inhibits Nitric Oxide Synthase mRNA Induction by Interleukin-1.ALPHA. and Tumor Necrosis Factor-.ALPHA. in Vascular Smooth Muscle Cells.
- Nitric Oxide Synthase mRNA in Endothelial Cells: Synergistic Induction by Interferon-.GAMMA., Tumor Necrosis Factor-.ALPHA. and Lipopolysaccharide and Inhibition by Dexamethasone.
- Drug oxidation activities of horseradish peroxidase, myoglobin and cytochrome P-450cam reconstituted with synthetic hemes.
- Regulations of Male-Dominant P-450Md mRNA in Rat Liver by Hormonal Factors and Xenobiotics.
- Inhibition of teleocidin-caused epidermal ornithine decarboxylase induction by phospholipase A2-, cyclooxygenase- and lipoxygenase-inhibitors.
- Synergistic Stimulation of Prostaglandin E2 Release by Epidermal Growth Factor and a Tumor Promoter Anthralin from Primary Cultures of Mouse Epidermal Cells.
- Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced increase in vascular permeability in mouse skin by lipoxygenase inhibitors.
- Comparison of some biochemical properties of epidermis in tumor promotion-susceptible and -resistant strains of mice.
- Induction of cytochrome P-450c and P-450d by metyrapone in the primary culture of rat hepatocytes.
- Nitric Oxide in Vascular Remodeling.
- Beneficial Circulatory Effect of L-Arginine.
- Tension-induced release of endothelium-derived relaxing factor; Possible role in establishment of desensitization of norepinephrine-induced contraction in rat aorta.
- Fractal Analysis of Fracture Surfaces and Simulation of Fracture Process Using Fractal Dimension Maps in Stainless Steels Fatigued by Repeated Bending