Mode of potentiating action of cocaine in morphine analgesia.
スポンサーリンク
概要
- 論文の詳細を見る
The mechanism of antinociceptive interactions among morphine, cocaine and alcohol was studied in mice, guinea pigs and rabbits. In the tail-pressure test in mice, cocaine and alcohol alone showed almost no antinociceptive effects at doses up to 8 mg/kg, s.c., and 4 g/kg, i.g., respectively. Alcohol at 2 g/kg, i.g., also did not influence the effect of morphine, while cocaine at 4 mg/kg, s.c., significantly potentiated the antinociceptive effects of not only morphine but also pentazocine. In an analysis of serum and brain concentration levels of morphine in mice, when morphine and cocaine were simultaneously administered at 2 mg/kg, s.c., and 4 mg/kg, s.c., respectively, both serum and brain levels of morphine showed neither increase nor decrease in comparison with the levels in mice administered morphine alone. In myenteric plexus-longitudinal muscle preparations of isolated guinea pig ileum, 1 μM cocaine enhanced the agonistic effects of both pentazocine and ethylketocyclazocine. Furthermore, cocaine as well as ethylketocyclazocine showed naloxone-reversible agonistic effects in isolated rabbit vas deferens. These results indicate that cocaine may potentiate the antinociceptive effects of morphine and pentazocine by acting on the κ-opioid receptors as an agonist.
著者
-
Shimada Akira
Department of Chemistry Faculty of Science Osaka City University
-
YANAGITA Tomoji
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental Animals
-
YANAGITA Tomoji
Department of Pharmacology, Preclinical Research Laboratories
-
Shimada Akira
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental Animals
-
TSUDA Toshiharu
Department of Pharmacology, Preclinical Research Laboratories, Central Institute for Experimental Animals
関連論文
- Omenn Syndrome-Review of Several Phenotypes of Omenn Syndrome and RAG1/RAG2 Mutations in Japan
- Malignant Insulinoma with Extensive Liver Metastases Presenting as Disturbance of Consciousness
- IMMUNOPATHOLOGICAL FEATURES OF LADA VS. SPIDDM : CURRENT STRATEGY FOR PREVENTION
- IgG1 Is the Dominant Subclass of Antibody against Glutamic Acid Decarboxylase among Type 1 Diabetes in Japanese
- Evaluation of the diagnostic accuracy of the stop codon (SC) assay for identifying protein-truncating mutations in the BRCA1 and BRCA2 genes in familial breast cancer
- Prognostic significance of the BAALC isoform pattern and CEBPA mutations in pediatric acute myeloid leukemia with normal karyotype : a study by the Japanese Childhood AML Cooperative Study Group
- Low Frequency of KIT Gene Mutation in Pediatric Acute Myeloid Leukemia with inv(16)(p13q22) : A Study of the Japanese Childhood AML Cooperative Study Group
- ANTIOXIDANT ACCELERATES TRANSFER OF DIABETES INTO AUTOIMMUNE DIABETES OF MICE
- The Feasibility of Altering the Hair Cycle via the Induction of Apoptosis by Cyclosporin A
- THEBAINE METABOLITES IN THE URINE OF RHESUS MONKEYS
- Effect of Combination Therapy of a Rapid-Acting Insulin Secretagogue (Glinide) with Premixed Insulin in Type 2 Diabetes Mellitus
- INFLUENCE OF TOLERANCE TO AND PHYSICAL DEPENDENCE ON OPIOID ANALGESICS ON CORTICAL EVOKED POTENTIAL IN RATS
- Beta cell dysfunction and its clinical significance in gestational diabetes
- Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
- Normal glucose tolerance with high HbA1c levels observed in two cases of Hb variants
- Higher level of serum vascular endothelial growth factor in type 2 diabetic patients with diabetic retinopathy hospitalized for hyperglycemic state
- CD20-negative Epstein-Barr virus-associated post-transplant lymphoproliferative disease refractory to rituximab in a patient with severe aplastic anemia
- Excellent outcomes of children with CML treated with imatinib mesylate compared to that in pre-imatinib era
- Effects of Pretreatment with Low-dose Metformin on Metabolic Parameters and Weight Gain by Pioglitazone in Japanese Patients with Type 2 Diabetes
- Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22)
- RAS mutations are frequent in FAB type M4 and M5 of acute myeloid leukemia, and related to late relapse : a study of the Japanese Childhood AML Cooperative Study Group
- Prevention of disaster
- Glycated albumin to glycated hemoglobin ratio reflects postprandial glucose excursion and relates to beta cell function in both type 1 and type 2 diabetes
- Effect of obesity on declining beta cell function after diagnosis of type 2 diabetes : a possible link suggested by cross-sectional analysis
- Excellent outcome of allogeneic bone marrow transplantation for Fanconi anemia using fludarabine-based reduced-intensity conditioning regimen
- Associations of Insulin Resistance and Glycemic Control with the Risk of Kidney Stones
- Risk for Future Diabetes among Individuals with High-normal Glycemia at 40 Years of Age
- Mode of potentiating action of cocaine in morphine analgesia.
- The Crystal Structure of m-Aminobenzenearsonic Acid
- The Crystal and Molecular Structure of Pyromellitic Acid Dihydrate (Benzene-1,2,4,5-tetracarboxylic Acid Dihydrate)
- The Crystal Structure of Quinolinic Acid
- High WT1 mRNA expression after induction chemotherapy and FLT3-ITD have prognostic impact in pediatric acute myeloid leukemia : a study of the Japanese Childhood AML Cooperative Study Group
- The Molecular and Crystal Structure of 3,4-Furandicarboxylic Acid Dimethylester
- Crystal Structures of 1-(2-Thiazolylazo)-6-bromo-2-naphthol and Bis(1-(2-thiazolylazo)-2-naphthol)iron(II)
- The Crystal Structure of Dipicolinic Acid Monohydrate
- The Crystal Structure of Cinchomeronic Acid
- The Crystal and Molecular Structure of Nagilactone A Diacetate
- Slowly Progressive Type 1 Diabetes Treated with Metformin for Five Years after Onset
- The Crystal Structure of Pyrazinic Acid